EMIGLITATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25NO7
Molecular Weight	355.3829
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=CC=C(OCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)C=C1

InChI

InChIKey=NWWORXYTJRPSMC-QKPAOTATSA-N

InChI=1S/C17H25NO7/c1-2-24-17(23)11-3-5-12(6-4-11)25-8-7-18-9-14(20)16(22)15(21)13(18)10-19/h3-6,13-16,19-22H,2,7-10H2,1H3/t13-,14+,15-,16-/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3130257

Emiglitate (BAYo1248/ BAY- O-1248) a deoxynojirimycin derivative, is an alpha-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release. It was investigated the effect of prolonged administration of this drug on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. And was obtained, that drug reduced postprandial hyperglycaemia and insulin requirements

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Maltase-glucoamylase 9 Target ID: CHEMBL2074 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3100764	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 91 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3130257	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet.	1986 Aug	3728357
Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice.	1987 Jan	3100764

Patents

Sample Use Guides

In Vivo Use Guide

single doses of 10, 20 and 40 mg emiglitate

Route of Administration: Oral

In Vitro Use Guide

In islet homogenate emiglitate strongly and dose-dependently inhibited the activity of acid glucan-1,4-alpha-glucosidase (EC50 approximately 10(-6) M) without affecting other classical lysosomal enzyme activities. The emiglitate-induced inhibition curve for glucose-stimulated insulin secretion from isolated islets was remarkably similar to the inhibition curve for acid glucan-1,4-alpha-glucosidase

Name

Type

Language

EMIGLITATE

Official Name

English

EMIGLITATE [JAN]

Common Name

English

emiglitate [INN]

Common Name

English

BAY-O-1248

Code

English

EMIGLITATE [MART.]

Common Name

English

BAY O 1248

Code

English

ETHYL P-(2-((2R,3R,4R,5S)-3,4,5-TRIHYDROXY-2-(HYDROXYMETHYL)PIPERIDINO)ETHOXY)BENZOATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471