EMIGLITATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25NO7
Molecular Weight	355.3829
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=CC=C(OCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)C=C1

InChI

InChIKey=NWWORXYTJRPSMC-QKPAOTATSA-N

InChI=1S/C17H25NO7/c1-2-24-17(23)11-3-5-12(6-4-11)25-8-7-18-9-14(20)16(22)15(21)13(18)10-19/h3-6,13-16,19-22H,2,7-10H2,1H3/t13-,14+,15-,16-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H25NO7
Molecular Weight	355.3829
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3130257

Emiglitate (BAYo1248/ BAY- O-1248) a deoxynojirimycin derivative, is an alpha-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release. It was investigated the effect of prolonged administration of this drug on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. And was obtained, that drug reduced postprandial hyperglycaemia and insulin requirements

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Maltase-glucoamylase 9 Target ID: CHEMBL2074 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3100764	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 93 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3130257	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice.	1987-01	3100764
Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet.	1986-08	3728357

Patents

Sample Use Guides

In Vivo Use Guide

single doses of 10, 20 and 40 mg emiglitate

Route of Administration: Oral

In Vitro Use Guide

In islet homogenate emiglitate strongly and dose-dependently inhibited the activity of acid glucan-1,4-alpha-glucosidase (EC50 approximately 10(-6) M) without affecting other classical lysosomal enzyme activities. The emiglitate-induced inhibition curve for glucose-stimulated insulin secretion from isolated islets was remarkably similar to the inhibition curve for acid glucan-1,4-alpha-glucosidase

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:57:07 GMT 2025` Edited by `admin` on `Wed Apr 02 06:57:07 GMT 2025`
Record UNII	PF8AB2IBUM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EMIGLITATE

Official Name

English

BAY-O-1248

Preferred Name

English

EMIGLITATE [JAN]

Common Name

English

emiglitate [INN]

Common Name

English

EMIGLITATE [MART.]

Common Name

English

BAY O 1248

Code

English

ETHYL P-(2-((2R,3R,4R,5S)-3,4,5-TRIHYDROXY-2-(HYDROXYMETHYL)PIPERIDINO)ETHOXY)BENZOATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471