U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

Showing 6181 - 6190 of 167129 results

Status:
Investigational
Source:
USAN:Acetiamine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Acetiamine (syn. thianeurone or diacetamine) is a thiamine derivative which is rarely used in pharmaceuticals. It is lipid-soluble. It has been studied for the treatment of rheumatic diseases.
Status:
Investigational
Source:
INN:acetorphine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acetorphine is a synthetic narcotic analgesic. Acetorphine was reported to have uses in veterinary medicine with pronounced advantages in the immobilization of the giraffe in which toxic effects were reduced as compared to the effects of etorphine. In July 1966, the Director-General of the World Health Organization informed the Secretary-General that WHO had arrived at the conclusion that etorphine and acetorphine should be included in Schedule I of the Convention, since they could give rise to similar abuse, and produce similar ill effects as the substances already listed therein. Acetorphine is a Schedule I controlled substance in the United States.
Status:
Investigational
Source:
INN:dulozafone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dulozafone is an anticonvulsant and anxiolytic agent. Dulozafone was derived from glycine. Neuro-pharmacological experiments had demonstrated that dulozafone shows the same pharmacological activity as benzodiazepines and a good in vivo affinity for the benzodiazepine receptor. Dulozafone is a pro-drug, metabolized in vivo to an active form. One of its putative metabolites could be ortho-chloro-diazepam, which is pharmacologically active. Dulozafone had the same anticonvulsant effect on kindled seizures as diazepam. It is potent inhibitor of convulsions and epileptic discharges of fully kindled rats. Dulozafone exerts their anticonvulsant properties in inhibiting the propagation of the epileptic discharge from amygdala to other cerebral structures, particularly those implicated in the motor generalization, such as the substantia nigra.
Status:
Investigational
Source:
INN:dulofibrate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dulofibrate is a fibrate derivative with antilipidemic activity. Unlike clofibrate, dulofibrate is selective for a reduction in triglycerides. Dulofibrate decreased the conjugation of nopol. Dulofibrate exhibited a clofibrate-like effect on the induction of hepatic drug-metabolizing enzymes, characterized by an increase in lauric acid 12-hydroxylation and bilirubin UDP-glucuronosyltransferase activities. Dulofibrate and fenofibrate have been shown to possess an equal potency as peroxisome proliferators.
Status:
Investigational
Source:
INN:duometacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Duometacin is indomethacin derivative. It was developed as analgesic and anti-inflammatory agent.
Status:
Investigational
Source:
INN:bromociclen [INN]
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)


Bromociclen (5-(Bromomethyl)-1,2,3,4,7,7-hexachlorobicyclo[2.2.1]hept-2-ene; 5-(Bromomethyl)-1,2,3,4,7,7-hexachloro-2-norbornene) is a halogenated bicyclic insecticide. Bromociclen is used for the control of stored-product insects as well as against ecto-parasites.
Status:
Investigational
Source:
INN:bromchlorenone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Bromchlorenone is Halogenated benzazole derivative with potent antimicrobial activity against pathogenic fungi, molds and yeasts for topical use. Currently Bromchlorenone used as reagent for organic syntesys.
Status:
Investigational
Source:
INN:brometenamine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Brometenamine is organic compound with antibacterial properties.
Status:
Investigational
Source:
INN:brofaromine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Brofaromine (proposed brand name Consonar) is a reversible inhibitor of monoamine oxidase A (RIMA) developed by Ciba-Geigy for depression and anxiety disorders treatment. Brofaromine induces short, reversible and selective inhibition of brain MAO of type A in a dose-dependent manner in all brain regions. The largest decrease being found respectively in hippocampus, striatum and prefrontal cortex, regions having a rich monoaminergic innervation. Brofaromine also acts as a serotonin reuptake inhibitor, and its dual pharmacologic effects offered promise in the treatment of a wide spectrum of depressed patients while producing less severe anticholinergic side effects in comparison with older standard drugs like the tricyclic antidepressants. The compound was primarily researched in the treatment of depression and anxiety but its development was dropped before it was brought to market.
Status:
Investigational
Source:
INN:bromamide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Bromamid is derivative of parabromometanitrobenzoic acid with antiseptic and analgesic activity developed by Chugai Pharmaceutical

Showing 6181 - 6190 of 167129 results