DULOFIBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H14Cl2O3
Molecular Weight	325.187
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OC2=CC=C(Cl)C=C2

InChI

InChIKey=NIVDRJXCJCEFDD-UHFFFAOYSA-N

InChI=1S/C16H14Cl2O3/c1-16(2,21-14-9-5-12(18)6-10-14)15(19)20-13-7-3-11(17)4-8-13/h3-10H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H14Cl2O3
Molecular Weight	325.187
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2885979 | https://adisinsight.springer.com/drugs/800002687 | https://www.chemarc.com/content/chemicals/dulofibrate/64550

Dulofibrate is a fibrate derivative with antilipidemic activity. Unlike clofibrate, dulofibrate is selective for a reduction in triglycerides. Dulofibrate decreased the conjugation of nopol. Dulofibrate exhibited a clofibrate-like effect on the induction of hepatic drug-metabolizing enzymes, characterized by an increase in lauric acid 12-hydroxylation and bilirubin UDP-glucuronosyltransferase activities. Dulofibrate and fenofibrate have been shown to possess an equal potency as peroxisome proliferators.

Approval Year

PubMed

Title	Date	PubMed
Influence of food on the absorption of the p-chlorophenolic ester of chlorophenoxyisobutyric acid in man.	1984 Mar	6712867
Differential induction profile of drug-metabolizing enzymes after treatment with hypolipidaemic agents.	1987 Apr	2885979

Patents

Sample Use Guides

In Vivo Use Guide

200 mg/kg per day once a day for five days

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:38:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:38:21 GMT 2023`
Record UNII	5K0215OMQX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DULOFIBRATE

Official Name

English

dulofibrate [INN]

Common Name

English

P-CHLOROPHENYL 2-(P-CHLOROPHENOXY)-2-METHYLPROPIONATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150