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Status:
Investigational
Source:
Cancer Treat Rep. Aug 1978;62(8):1173-6.: Phase 2 Human clinical trial Completed Neoplasms
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Hycanthone is a thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. It was clinically available for the treatment of human schistosomiasis. Anti-helmintic action relies on its ability to inhibit worm monoamine oxidase and cholinesterases. Hycanthone produced immediate side effects such as hepatotoxicity and gastrointestinal disturbances, and was consequently withdrawn. Hycanthone inhibits apurinic endonuclease-1 (APE1) by direct protein binding. Hycanthone was used in the 1980s as antitumor agents, it was pulled out of Phase II trials.
Class (Stereo):
CHEMICAL (MIXED)
Naboctate (SP-325) is a synthetic cannabinoid receptor agonist, which has antiemetic, sedative, anxiolytic and anti-glaucoma properties. In a normotensive rabbit model, topically applied naboctate in aqueous solution induced dose-related decreases in intraocular pressure.
Status:
Investigational
Source:
INN:flumetramide [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
FLUMETRAMIDE is a skeletal muscle relaxant.
Status:
Investigational
Source:
JAN:POTASSIUM GUAIACOLSULFONATE [JAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Potassium 4-Hydroxy-3-methoxybenzenesulfonate Hemihydrate is the hemihydrate of potassium guaiacolsulfonate. Guaiacolsulfonic acid, commonly used in the form of potassium guaiacolsulfonate. Guaiacolsulfonic acid is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. Guaiacolsulfonate works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. 'is reduces chest congestion by making coughs more productive.
Class (Stereo):
CHEMICAL (ACHIRAL)
Thiofuradene (also known as Furidin) is a imidazolidinethione derivative patented by Norwich Pharmacal Co. as an anthelmintic and growth stimulant. Thiofuradene exerts favor influences on combating Pasteurella multocida, Eimeria tenella, and other infections. Thiofuradene added in a dose of 30 mg/day to the ration for 5 to 30 days increased the egg production of chickens several days after the beginning of its administration.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Picofosforic acid is the laxative.
Status:
Investigational
Source:
NCT00160134: Phase 2 Interventional Completed Congestive Heart Failure
(2005)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Derenofyllin (SLV320) is a selective adenosine A1 receptor antagonist, which is under investigation for the treatment of heart failure with renal dysfunction. Adverse events considered related to SLV320 were dizziness, nausea, transient hypertension and transient hypotension.
Status:
Investigational
Source:
NCT01326780: Phase 2 Interventional Completed Acne Vulgaris
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
Arch Toxicol. Jan 2012;86(1):45-53.: Not Applicable Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Class (Stereo):
CHEMICAL (UNKNOWN)
ISOMAZOLE is a cardiovascular agent with both inotropic and vasodilator activities. It acts primarily as a phosphodiesterase inhibitor.