POTASSIUM 4-GUAIACOLSULFONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7O5S.K
Molecular Weight	242.291
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POTASSIUM 4-GUAIACOLSULFONATE

Structure Search

SMILES

[K+].COC1=CC(=CC=C1O)S([O-])(=O)=O

InChI

InChIKey=QFRKWSPTCBGLSU-UHFFFAOYSA-M

InChI=1S/C7H8O5S.K/c1-12-7-4-5(13(9,10)11)2-3-6(7)8;/h2-4,8H,1H3,(H,9,10,11);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H7O5S
Molecular Weight	203.192
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/758448 | https://www.ncbi.nlm.nih.gov/pubmed/21238758 | https://www.ncbi.nlm.nih.gov/pubmed/26202585 | https://www.ncbi.nlm.nih.gov/pubmed/30984442

Potassium 4-Hydroxy-3-methoxybenzenesulfonate Hemihydrate is the hemihydrate of potassium guaiacolsulfonate. Guaiacolsulfonic acid, commonly used in the form of potassium guaiacolsulfonate. Guaiacolsulfonic acid is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. Guaiacolsulfonate works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. 'is reduces chest congestion by making coughs more productive.

Approval Year

PubMed

Title	Date	PubMed
[Determination of sodium camphosulfonate in the presence of potassium guaiacolsulfonate].	1963 Jan	14013660
Determination of potassium guaiacolsulfonate by ion-pairing partition chromatography.	1975 Mar	237875
Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography.	1977 Jun	18008
Applications of paired ion high-pressure liquid chromatography: quantitative determination of potassium guaiacolsulfonate and other ingredients in cough syrups.	1979 Jan	758448
Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations.	1984 May-Jun	6746476
Determination of the chemical constituents and spectral properties of commercial and NF reference standard potassium guaiacolsulfonate: implications of the findings on compendial analytical methodology.	1984 Sep	6491940
Physicochemical properties and method for determination of potassium guaiacolsulfonate.	1987 Jul-Aug	3624174
Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration.	2011 Feb 15	21238758
A New UPLC Approach for the Simultaneous Quantitative Estimation of Four Compounds in a Cough Syrup Formulation.	2016 Jan	26202585
Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder.	2019	30984442

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:12:01 UTC 2023` Edited by `admin` on `Fri Dec 15 17:12:01 UTC 2023`
Record UNII	ZL9GA44H2A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POTASSIUM 4-GUAIACOLSULFONATE

Systematic Name

English

MONOPOTASSIUM 4-HYDROXY-3-METHOXYBENZENESULPHONATE

Systematic Name

English

POTASSIUM 4-HYDROXY-3-METHOXYBENZENESULFONATE

Systematic Name

English

4-HYDROXY-3-METHYOXYBENZENESULFONIC ACID, POTASSIUM SALT

Common Name

English

MONOPOTASSIUM 4-HYDROXY-3-METHOXYBENZENESULFONATE

Systematic Name

English

POTASSIUM GUAIACOLSULFONATE [JAN]

Common Name

English

POTASSIUM 4-GUAIACOLSULFONATE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m9025