U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H7O5S.K
Molecular Weight 242.291
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of POTASSIUM 4-GUAIACOLSULFONATE

SMILES

[K+].COC1=CC(=CC=C1O)S([O-])(=O)=O

InChI

InChIKey=QFRKWSPTCBGLSU-UHFFFAOYSA-M
InChI=1S/C7H8O5S.K/c1-12-7-4-5(13(9,10)11)2-3-6(7)8;/h2-4,8H,1H3,(H,9,10,11);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H7O5S
Molecular Weight 203.192
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Potassium 4-Hydroxy-3-methoxybenzenesulfonate Hemihydrate is the hemihydrate of potassium guaiacolsulfonate. Guaiacolsulfonic acid, commonly used in the form of potassium guaiacolsulfonate. Guaiacolsulfonic acid is used as an expectorant for relieving symptoms of cough and mucus in the chest due to respiratory infections, asthma, colds, or hay fever. Guaiacolsulfonate works by thinning mucus (phlegm) in the lungs and making it less sticky and easier to cough up. 'is reduces chest congestion by making coughs more productive.

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of potassium guaiacolsulfonate by ion-pairing partition chromatography.
1975 Mar
Physicochemical properties and method for determination of potassium guaiacolsulfonate.
1987 Jul-Aug
Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration.
2011 Feb 15
A New UPLC Approach for the Simultaneous Quantitative Estimation of Four Compounds in a Cough Syrup Formulation.
2016 Jan
Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder.
2019
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:12:01 GMT 2023
Edited
by admin
on Fri Dec 15 17:12:01 GMT 2023
Record UNII
ZL9GA44H2A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM 4-GUAIACOLSULFONATE
MI  
Systematic Name English
MONOPOTASSIUM 4-HYDROXY-3-METHOXYBENZENESULPHONATE
Systematic Name English
POTASSIUM 4-HYDROXY-3-METHOXYBENZENESULFONATE
Systematic Name English
4-HYDROXY-3-METHYOXYBENZENESULFONIC ACID, POTASSIUM SALT
Common Name English
MONOPOTASSIUM 4-HYDROXY-3-METHOXYBENZENESULFONATE
Systematic Name English
POTASSIUM GUAIACOLSULFONATE [JAN]
Common Name English
POTASSIUM 4-GUAIACOLSULFONATE [MI]
Common Name English
Code System Code Type Description
MERCK INDEX
m9025
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
PRIMARY Merck Index
CHEBI
32033
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
PRIMARY
CAS
16241-25-1
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
PRIMARY
PUBCHEM
23679005
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
PRIMARY
CAS
74499-12-0
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
NON-SPECIFIC SUBSTITUTION
FDA UNII
ZL9GA44H2A
Created by admin on Fri Dec 15 17:12:01 GMT 2023 , Edited by admin on Fri Dec 15 17:12:01 GMT 2023
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE