ISOMAZOLE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	UNKNOWN
Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ISOMAZOLE

Structure Search

SMILES

COC1=C(C=CC(=C1)[S+](C)[O-])C2=NC3=CC=NC=C3N2

InChI

InChIKey=JQUKCPUPFALELS-UHFFFAOYSA-N

InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3999023 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.1987.tb00509.x

ISOMAZOLE is a cardiovascular agent with both inotropic and vasodilator activities. It acts primarily as a phosphodiesterase inhibitor.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.	1985 May	3999023
Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).	1986 Apr	3007737
Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats.	1989 Oct	2612774
Toxicological evaluation of the cardiotonic isomazole in the dog.	1989 Oct	2612775

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:10:31 GMT 2023` Edited by `admin` on `Fri Dec 15 17:10:31 GMT 2023`
Record UNII	L8O2GV23DC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOMAZOLE

Official Name

English

1H-IMIDAZO(4,5-C)PYRIDINE, 2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-

Systematic Name

English

2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-1H-IMIDAZO(4,5-C)PYRIDINE

Systematic Name

English

isomazole [INN]

Common Name

English

Code System Code Type Description

PUBCHEM

55690

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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FDA UNII

L8O2GV23DC

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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EVMPD

SUB08321MIG

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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SMS_ID

100000082830

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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INN

5839

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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EPA CompTox

DTXSID3020754

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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NCI_THESAURUS

C175804

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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CAS

86315-52-8

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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ChEMBL

CHEMBL2110680

Created by admin on Fri Dec 15 17:10:31 GMT 2023 , Edited by admin on Fri Dec 15 17:10:31 GMT 2023

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Related Record Type Details


					L8O2GV23DC

ISOMAZOLE

ACTIVE MOIETY