ISOMAZOLE

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NCATS

Details

Stereochemistry	UNKNOWN
Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ISOMAZOLE

Structure Search

SMILES

COC1=C(C=CC(=C1)[S+](C)[O-])C2=NC3=C(N2)C=NC=C3

InChI

InChIKey=JQUKCPUPFALELS-UHFFFAOYSA-N

InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C14H13N3O2S
Molecular Weight	287.337
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3999023 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.1987.tb00509.x

ISOMAZOLE is a cardiovascular agent with both inotropic and vasodilator activities. It acts primarily as a phosphodiesterase inhibitor.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats.	1989-10	2612774
Toxicological evaluation of the cardiotonic isomazole in the dog.	1989-10	2612775
Roles for Ca++ and cyclic AMP in mediating the cardiotonic actions of isomazole (LY175326).	1986-04	3007737
Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.	1985-05	3999023

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:41:24 GMT 2025` Edited by `admin` on `Mon Mar 31 18:41:24 GMT 2025`
Record UNII	L8O2GV23DC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOMAZOLE

Official Name

English

isomazole [INN]

Preferred Name

English

1H-IMIDAZO(4,5-C)PYRIDINE, 2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-

Systematic Name

English

2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-1H-IMIDAZO(4,5-C)PYRIDINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

55690

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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FDA UNII

L8O2GV23DC

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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EVMPD

SUB08321MIG

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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SMS_ID

100000082830

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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INN

5839

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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EPA CompTox

DTXSID3020754

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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NCI_THESAURUS

C175804

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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CAS

86315-52-8

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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ChEMBL

CHEMBL2110680

Created by admin on Mon Mar 31 18:41:24 GMT 2025 , Edited by admin on Mon Mar 31 18:41:24 GMT 2025

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Related Record Type Details


					L8O2GV23DC

ISOMAZOLE

ACTIVE MOIETY