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Search results for icosapent root_names_stdName in Standardized Name (approximate match)
Status:
Investigational
Source:
NCT02575638: Phase 1 Interventional Unknown status Malignant Lymphoma of Extranodal and/or Solid Organ Site
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Camptothecin-20(S)-O-propionate (CZ48) is a prodrug of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with potential antineoplastic activity. Upon entry into cells, camptothecin-20(S)-O-propionate is hydrolyzed by esterases into the active form camptothecin. Camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. CZ48 is being investigated in clinical trials for the treatment of advanced solid tumors and lymphomas.
Status:
Investigational
Source:
NCT02537938: Phase 1 Interventional Completed Alzheimer's Disease
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03152370: Phase 1 Interventional Completed Neoadjuvant Therapy in Rectal Cancer
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Monophosphothiamine is thiamine derivative used for the treatment of neuritis, polyneuritis, asthenic conditions (weakness), as an additional remedy for chronic blood circulation insufficiency, chronic gastritis accompanied by motor and secretory disorders functions of the stomach. Monophosphothiamine underwent metabolic phosphorylation to active metabolite thiamine pyrophosphate, that acts as a coenzyme in the different metabolic process.
Status:
Investigational
Source:
NCT01424384: Phase 1 Interventional Completed Depressive Disorder and Anxiety Disorders
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
GlaxoSmithKline was developing GSK-424887as a dual antagonist of the human neurokinin receptor 1 and inhibitor of the serotonin transporter. GSK 424887 participated in phase I clinical trials for the treatment of depressive disorder and anxiety disorder. However, further development of GSK 424887 apparently was discontinued.
Status:
Investigational
Source:
NCT04434937: Phase 2 Interventional Completed Lymphoma
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT01931943: Phase 1 Interventional Unknown status Advanced Breast Cancer
(2013)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Qilu Pharmaceutical has developed selatinib, an orally available dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 receptor (HER-2) for the treatment of cancer. Selatinib participates in phase I of the ongoing clinical trial to evaluate its safety and tolerability, and explore the maximum tolerated dose (MTD) and dose-limiting toxicity in patients with advanced breast cancer.
Status:
Investigational
Source:
NCT04120116: Phase 2 Interventional Completed Sensorineural Hearing Loss
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
CHIR 99021 is a selective, pyridimidine-based, glycogen synthase kinase 3 inhibitor that is effective at low nanomolar concentrations in enzyme assays and submicromolar concentrations in isolated cells and tissues. Chiron was developing CHIR 99021 for potential use in the treatment of type 2 diabetes mellitus. CHIR 99021 promoted insulin-mediated glucose uptake and increased glucose disposal in rodent models of diabetes. However, there has been no recent development reported.
Status:
Investigational
Source:
INN:esamisulpride [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT02435121: Phase 2 Interventional Completed Neoplasm Malignant
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
