Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H20N2O5 |
| Molecular Weight | 404.4153 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)O[C@]1(CC)C(=O)OCC2=C1C=C3N(CC4=CC5=CC=CC=C5N=C34)C2=O
InChI
InChIKey=YCNIQYLWIPCLNY-QHCPKHFHSA-N
InChI=1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1
| Molecular Formula | C23H20N2O5 |
| Molecular Weight | 404.4153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Not to be confused with a CD38 inhibitor CZ-48 (https://www.ncbi.nlm.nih.gov/pubmed/31128467)
Curator's Comment: Not to be confused with a CD38 inhibitor CZ-48 (https://www.ncbi.nlm.nih.gov/pubmed/31128467)
Camptothecin-20(S)-O-propionate (CZ48) is a prodrug of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with potential antineoplastic activity. Upon entry into cells, camptothecin-20(S)-O-propionate is hydrolyzed by esterases into the active form camptothecin. Camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. CZ48 is being investigated in clinical trials for the treatment of advanced solid tumors and lymphomas.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:34:35 GMT 2023
by
admin
on
Sat Dec 16 09:34:35 GMT 2023
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| Record UNII |
4S145C552U
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| Record Status |
Validated (UNII)
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| Record Version |
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194414-69-2
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DTXSID30173074
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9887472
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admin on Sat Dec 16 09:34:36 GMT 2023 , Edited by admin on Sat Dec 16 09:34:36 GMT 2023
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SALT/SOLVATE -> PARENT |
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TARGET -> INHIBITOR |
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SOLVATE->ANHYDROUS |
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ACTIVE MOIETY |
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