U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 471 - 480 of 1355 results

Status:
Possibly Marketed Outside US
Source:
NCT01657032: Phase 4 Interventional Completed Diarrhea
(2010)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Montmorillonite is a very soft phyllosilicate group of minerals that form when they precipitate from water solution as microscopic crystals, known as clay. Montmorillonite is a typical weathering of aluminosilicates and one of the main minerals in many soils. Montmorillonite is the main component of bentonite that found in many sedimentary rocks. Due to its high adsorption properties, montmorillonite is used in the oil, textile, paper, and soap industries as an active component of bleaching and cloth clay. Montmorillonite is used in the oil drilling industry as a component of drilling mud, making the mud slurry viscous, which helps in keeping the drill bit cool and removing drilled solids. It is also used as a soil additive to hold soil water in drought-prone soils, used in the construction of earthen dams and levees, and to prevent the leakage of fluids. It is also used as a component of foundry sand and as a desiccant to remove moisture from air and gases. Montmorillonite is effective as an adsorptive of heavy metals and has been used and eaten from ancient time till now. For external use, montmorillonite has been used to treat contact dermatitis and in the materials produced for orthopedics, traumatology, dentistry.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

D&C RED NO. 7 is an inactive component of CONZIP®, which is an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
Status:
Possibly Marketed Outside US
Source:
NCT00442962: Phase 4 Interventional Completed HIV Infections
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Maleic acid monosodium salt. Used in water soluble polymers preparation.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Acetyltryptophan,DL- functions readily as a component of the food in place of the free amino acid - a greater amount of acetyltryptophane,DL- than dl-tryptophane may be available to man. Acetyltryptophan,DL- is used as an additive in the protein microbubbles, used in various biomedical applications such as contrast imaging, targeted drug and gene delivery, delivery of drugs through blood brain barrier (BBB) and IV O2 delivery etc. In the breast cancer biomarkers search, lower levels of endogenous metabolite Acetyltryptophan, DL- was identified in the fluid from the affected breasts compared to the control breast fluid.
Status:
Possibly Marketed Outside US
Source:
NCT00797589: Phase 4 Interventional Completed Valve Surgery
(2009)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Malic acid is a tart-tasting organic dicarboxylic acid that contributes to the taste of many sour or tart foods such as apples. Sodium Malate is the sodium salt of Malic Acid. Malic Acid and Sodium Malate can be found in a wide range of cosmetics and personal care products. Sodium Malate functions as a skin conditioning agent-humectant. As a food additive, Sodium Malate has the E number E350. Sodium Malate has demonstrated protective effect on cisplatin-induced toxicity in mice. Sodium malate could become a useful agent for the reduction of CDDP-induced toxicity, particularly nephrotoxicity and hepatotoxicity.
Status:
Possibly Marketed Outside US
Source:
VIVACE by Takeda Chemical Industries
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Delapril is a lipophilic nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor, which has been shown to exert potent ACE inhibitory activity and is marketed as an antihypertensive drug. Delapril has been shown to exist in solution as a mixture of s-cis and s-trans conformational isomers, as a result of restricted rotation about the amide bond.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Tasosartan is a long-acting angiotensin II (AngII) receptor blocker. Tasosartan is infrequently in the treatment of hypertension and heart failure. The manufacturer withdrew it from FDA review after phase III clinical trials showed elevated transaminases. Tasosartan blocks the renin-angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor that mediates most, if not all, of the important actions of Ang II. Tasosartan binds reversibly to the AT1 receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance.
Status:
Possibly Marketed Outside US
Source:
Acetylspiramycin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Acetylspiramycin for spiramycin acetylated derivatives, belonging to 16 membered ring macrolide. It is suitable for sensitive Staphylococcus, Streptococcus and Streptococcus pneumoniae induced by mild to moderate infections, such as pharyngitis, tonsillitis, sinusitis, otitis media, periodontitis, acute bronchitis, chronic bronchitis, pneumonia, non-gonococcal urethritis, skin and soft tissue infection, can be used for the selection of drugs for cryptosporidiosis, or as a treatment for pregnancy women of toxoplasmosis. The mechanism for Acetylspiramycin combined with sensitive microbial 50S ribosomal subunit, RNA dependent inhibition of protein synthesis and bacteriostasis.
Status:
Possibly Marketed Outside US
Source:
NCT02816567: Phase 4 Interventional Unknown status Patients Ongoing Elective Abdominal Laparoscopy
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
NCT00749515: Phase 4 Interventional Completed Transfusion-dependent Hemachromatosis
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Lidofenin is ligand for a coordination complex consisting of the radioisotope technetium-99m. Technetium Lidofenin is a nontoxic radiopharmaceutical that is used in radionuclide imaging for the clinical evaluation of hepatobiliary disorders in humans. Technetium lidofenin is indicated as a hepatobiliary imaging agent for the evaluation of hepatobiliary tract patency to differentiate jaundice resulting from hepatocellular causes from jaundice resulting from partial or complete biliary obstruction; to differentiate extrahepatic biliary atresia from neonatal hepatitis; to detect cystic duct obstruction associated with acute cholecystitis nd to detect bile leaks. Also, technetium Tc 99m lidofenin may be useful to detect intrahepatic cholestasis and to distinguish it from other hepatobiliary diseases, which involve hepatocyte damage. Following intravenous administration, technetium Tc 99m–labeled IDA derivatives, such as lidofenin, become bound to plasma proteins (mainly albumin). In the liver, in the space of Disse, technetium Tc 99m lidofenin becomes dissociated from the proteins and enters the hepatocyte by a mechanism similar to that of serum bilirubin. Technetium Tc 99m lidofenin traverses through the hepatocyte unmetabolized and enters the bile canaliculi. Flow beyond the canaliculi is influenced to a large extent by the tone of the sphincter of Oddi and the patency of the bile ducts. Clear visualization of the gallbladder and intestines, usually within 15 to 30 minutes of administration, demonstrates hepatobiliary tract patency.