U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.3O.4O2Si.H2O
Molecular Weight 360.3138
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Bentonite

SMILES

O.[O--].[O--].[O--].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O

InChI

InChIKey=GUJOJGAPFQRJSV-UHFFFAOYSA-N
InChI=1S/2Al.4O2Si.H2O.3O/c;;4*1-3-2;;;;/h;;;;;;1H2;;;/q2*+3;;;;;;3*-2

HIDE SMILES / InChI

Molecular Formula O2Si
Molecular Weight 60.0843
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Al
Molecular Weight 26.9815
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Montmorillonite is a very soft phyllosilicate group of minerals that form when they precipitate from water solution as microscopic crystals, known as clay. Montmorillonite is a typical weathering of aluminosilicates and one of the main minerals in many soils. Montmorillonite is the main component of bentonite that found in many sedimentary rocks. Due to its high adsorption properties, montmorillonite is used in the oil, textile, paper, and soap industries as an active component of bleaching and cloth clay. Montmorillonite is used in the oil drilling industry as a component of drilling mud, making the mud slurry viscous, which helps in keeping the drill bit cool and removing drilled solids. It is also used as a soil additive to hold soil water in drought-prone soils, used in the construction of earthen dams and levees, and to prevent the leakage of fluids. It is also used as a component of foundry sand and as a desiccant to remove moisture from air and gases. Montmorillonite is effective as an adsorptive of heavy metals and has been used and eaten from ancient time till now. For external use, montmorillonite has been used to treat contact dermatitis and in the materials produced for orthopedics, traumatology, dentistry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
IVY BLOCK - bentoquatam lotion

Approved Use

Helps prevent poison ivy, oak and sumac rash when applied before exposure.

Launch Date

2003
PubMed

PubMed

TitleDatePubMed
Modulation of human α4β2 nicotinic acetylcholine receptors by brominated and halogen-free flame retardants as a measure for in vitro neurotoxicity.
2012 Sep 3
Toxicity induced by F. poae-contaminated feed and the protective effect of Montmorillonite supplementation in broilers.
2014 Dec
Effectiveness of activated carbon and Egyptian montmorillonite in the protection against deoxynivalenol-induced cytotoxicity and genotoxicity in rats.
2015 Sep
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:03:33 GMT 2023
Edited
by admin
on Sat Dec 16 14:03:33 GMT 2023
Record UNII
A3N5ZCN45C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Bentonite
EP   FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
SMECTITE
Common Name English
BENTONITE [II]
Common Name English
E-558
Code English
BENTONITE [EP MONOGRAPH]
Common Name English
CI 77004
INCI  
INCI  
Official Name English
BENTONITE [HSDB]
Common Name English
BENTONITUM [WHO-IP LATIN]
Common Name English
ALUMINUM SILICATE HYDRATE
Common Name English
BENTONITE [MART.]
Common Name English
ALUMINIUM SILICATE HYDRATE
Common Name English
ALUM BENTONITE
VANDF  
Common Name English
ALUM BENTONITE [VANDF]
Common Name English
INS NO.558
Code English
WILKONITE
Brand Name English
COLLOIDAL CLAY
Common Name English
BENTONITE MAGMA [VANDF]
Common Name English
BENTONITE [WHO-IP]
Common Name English
BENTONITE MAGMA
VANDF  
Common Name English
BENTONITE [VANDF]
Common Name English
BENCLAY
Common Name English
BENTONITE [MI]
Common Name English
INS-558
Code English
BENTONITE [FCC]
Common Name English
BENTONITE [INCI]
Common Name English
BENTONITE [JAN]
Common Name English
Bentonite [WHO-DD]
Common Name English
CI 77004 [INCI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
DSLD 236 (Number of products:97)
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
JECFA EVALUATION INS-558
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
CFR 21 CFR 184.1155
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
CFR 21 CFR 178.3297
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C45678
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
CONCEPT Industrial Aid
DAILYMED
A3N5ZCN45C
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108915
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
PUBCHEM
71586775
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
MESH
D001546
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
HSDB
392
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
FDA UNII
A3N5ZCN45C
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-108-5
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
NCI_THESAURUS
C80916
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
RXCUI
1375
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY RxNorm
CAS
1302-78-9
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
MESH
C033214
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID6030782
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
BENTONITE
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY Description. A greyish white to cream-coloured, very fine, homogeneous powder; odourless. Solubility: Practically insoluble in water and most organic solvents; when added to water it swells to approximately 12 times its volume. Category: Suspending agent; viscosity-increasing agent. Storage: Bentonite should be kept in a tightly closed container. Additional information: Bentonite may also contain calcium, magnesium, and iron. Attention should be paid to the microbiological quality since Bentonite is of mineral origin. Definition: Bentonite is a natural, colloidal, hydrated aluminium silicate.
DRUG BANK
DB11306
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
EVMPD
SUB15260MIG
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
MERCK INDEX
m2327
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY Merck Index
EVMPD
SUB13006MIG
Created by admin on Sat Dec 16 14:03:33 GMT 2023 , Edited by admin on Sat Dec 16 14:03:33 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
http://apps.who.int/phint/pdf/b/Jb.6.1.44.pdf