SPIRAMYCIN II

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C45H76N2O15
Molecular Weight	885.0893
Optical Activity	UNSPECIFIED
Defined Stereocenters	19 / 19
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@H]([C@@H](C)O1)N(C)C)O[C@H]2\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](OC(C)=O)[C@H](OC)[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O[C@@]4([H])C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@@H](CC=O)C[C@H]2C

InChI

InChIKey=ZPCCSZFPOXBNDL-ZSTSFXQOSA-N

InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(51)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(52)29(5)57-37)42(54-12)34(59-30(6)49)23-35(50)55-26(2)16-14-13-15-17-33(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,51-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27-,28-,29+,31+,32+,33+,34-,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C45H76N2O15
Molecular Weight	885.0893
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	19 / 19
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.jslszy.com/template/p028e.htm

Acetylspiramycin for spiramycin acetylated derivatives, belonging to 16 membered ring macrolide. It is suitable for sensitive Staphylococcus, Streptococcus and Streptococcus pneumoniae induced by mild to moderate infections, such as pharyngitis, tonsillitis, sinusitis, otitis media, periodontitis, acute bronchitis, chronic bronchitis, pneumonia, non-gonococcal urethritis, skin and soft tissue infection, can be used for the selection of drugs for cryptosporidiosis, or as a treatment for pregnancy women of toxoplasmosis. The mechanism for Acetylspiramycin combined with sensitive microbial 50S ribosomal subunit, RNA dependent inhibition of protein synthesis and bacteriostasis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial 70S ribosome 179 Target ID: CHEMBL2363135 Sources: http://www.jslszy.com/template/p028e.htm	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Infections caused by sensitive staphylococcus, streptococcus, streptococcus pneumoniae 1 Sources: http://www.jslszy.com/template/p028e.htm	Curative		Approved 8429	Acetylspiramycin Approved Use Mild and moderate infections caused by sensitive staphylococcus, streptococcus, streptococcus pneumoniae.

PubMed

Title	Date	PubMed
A case of recurrence of congenital ocular toxoplasmosis with frosted branch angiitis (ocular toxoplasmosis with frosted branch angiitis).	2010 Dec 20	21319040

Patents

Sample Use Guides

In Vivo Use Guide

Adult dosage: a 0.2 ~ 0.3g, 4 times a day, for the first time double. Pediatric dose each day according to the weight of 20 ~ 30 mg/kg, 4 times a day

Route of Administration: Oral

In Vitro Use Guide

Resident mouse peritoneal macrophages cultured with acetylspiramycin (ASPM) (25-100 micrograms/ml for 18 h) showed a 62-92% reduction in phagocytosis. This was due to decreases in both attachment and ingestion of SRBC and was additional to the detachment of some macrophages from the surface of the culture chamber. Morphologically the macrophages were vacuolated, with some nuclear condensation. When the cells were cultured for a further 48 h after removal of ASPM there was almost complete functional and morphological recovery.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:01:12 UTC 2023` Edited by `admin` on `Fri Dec 15 17:01:12 UTC 2023`
Record UNII	05298J5WMU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SPIRAMYCIN II

Common Name

English

Spiramycin 2 [WHO-DD]

Common Name

English

FOROMACIDIN B

Common Name

English

SPIRAMYCIN 2

Common Name

English

SPIRAMYCIN II [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID4023595