Chlorbenzoxamine is an antimuscarinic agent used for the treatment of peptic ulcer disease and other functional gastrointestinal disorders. Chlorbenzoxamine, a structural analog of hydroxyzine, produces a unique antagonism of gastric ulceration induced in rats and dogs by various procedures. This effect is not accompanied by a significant gastric secretory depression or a reduction in gastric acid concentration. Chlorbenzoxamine does not show anticholinergic or antihistaminic activity in vitro but does produce a nonspecific depression of isolated smooth muscle. The antiulcer effect of chlorbenzoxamine in rats is abolished by hypophysectomy suggesting a central or endocrine mechanism of action.

Dimethylaminopropionylphenothiazine was first synthesized in 1951 by Swedish pharmaceutical company Astra AG. It demonstrated anesthetic and antispasmodic activities in vivo.

Trimethyldiphenylpropylamine (Recipavrin) is a methadon analog with antispasmodic properties. It exerts both musculotropic (antibarium) and anticholinergic action, relieves smooth muscle spasms, e.g. dysmenorrhea and pains associated with gallstones. It was marketed in Sweden in the 1960s as a spasmolytic drug under tradename Recipavrin.

Pinaverium, known under the brand name DICETEL, is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders and may be considered as effective first-lline therapy for patients with irritable bowel syndrome (IBS). Pinaverium is also used to help relieve symptoms caused by certain disorders of the gallbladder associated with secretion of bile. Pinaverium bromide is the common ingredient in formulations, mostly as oral tablets. Although it is not a currently approved drug by the FDA, pinaverium is available in over 60 countries including Canada. DICETEL® (pinaverium bromide) is a calcium antagonist which inhibits the calcium influx by blocking the voltage-dependent calcium channel at the smooth muscle cell level. It possesses a high degree of selectivity for the intestinal smooth muscle.

Nicofetamide is the antispasmodic drug used in the treatment intestinal spasms, painful menstruation with uterine spasms, pylorospasm, habitual vomiting, and other smooth muscle spasms. Nicofetamide has also been used to facilitate and accelerate labor. Nicofetamide is administered rectally in the form of suppositories at a dosage of 400–1200 mg per day. The drug was marketed in Italy by the Bracco company.

Emepronium bromide (Cetiprina) is a quarternary ammonium compound with anticholinergic effects. It is mainly used in the treatment of urinary frequency, urge and urge incontinence and is usually administered orally and occasionally intramuscularly. Emepronium bromide was introduced into Britain, after having been used in Sweden for a number of years. The drug was advocated especially for elderly patients suffering from nocturia and urgency with incontinence, when these were due to causes other than obstruction. It was also advocated for enuresis and hypertonic bladder states following surgery or radiotherapy.

Idanpramine is an antimuscarinic that has been used as the hydrochloride and sulfate salts in the relief of visceral spasms.

Dihexyverine (Metaspas, Spasmodex) is an anticholinergic and direct smooth muscle relaxant (spasmolytic). Dihexyverine is sold in France under the brand name Spasmodex. It is indicated for the treatment of the gastrointestinal tract disorders. Dihexyverine is a muscarinic acetylcholine receptor antagonist.

Poldine is an antimuscarinic drug, containing quaternary nitrogen. It is a selective inhibitor of gastric secretion. Administration of poldine leads to a 50% reduction of the volume and acid output of gastric juice without troublesome side-effects. Poldine was used for the treatment of gastric and duodenal ulcer under tradename "Nacton".

Ciclonium bromide is an antimuscarinic agent that acts by action by directly relaxing the smooth muscles. It is not approved in the USA, but available was marketed in other countries for functional or organic disorders associated with anxiety and emotional tension e.g. gastric and duodenal ulcers, gastritis, hypersecretion and gastric discomfort, spastic constipation, bile duct dyskinesia, renal colic, and dysmenorrhoea.