Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C26H41BrNO4 |
Molecular Weight | 511.512 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C(C[N+]4(CCOCC[C@@H]2CC[C@H]3C[C@@H]2C3(C)C)CCOCC4)C(Br)=C1
InChI
InChIKey=DDHUTBKXLWCZCO-BVSLBCMMSA-N
InChI=1S/C26H41BrNO4/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27/h15,17,19,21-22H,5-14,16,18H2,1-4H3/q+1/t19-,21-,22-/m0/s1
Pinaverium, known under the brand name DICETEL, is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders and may be considered as effective first-lline therapy for patients with irritable bowel syndrome (IBS). Pinaverium is also used to help relieve symptoms caused by certain disorders of the gallbladder associated with secretion of bile. Pinaverium bromide is the common ingredient in formulations, mostly as oral tablets. Although it is not a currently approved drug by the FDA, pinaverium is available in over 60 countries including Canada. DICETEL® (pinaverium bromide) is a calcium antagonist which inhibits the calcium influx by
blocking the voltage-dependent calcium channel at the smooth muscle cell level. It possesses a high degree of selectivity for the intestinal smooth muscle.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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1.75 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Dicetel Approved UseDICETEL® (pinaverium bromide) is indicated:
- for the treatment and relief of symptoms associated with irritable bowel syndrome (IBS):
abdominal pain, bowel disturbances and intestinal discomfort.
- for the treatment of symptoms related to functional disorders of the biliary tract. |
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Palliative | Dicetel Approved UseDICETEL® (pinaverium bromide) is indicated:
- for the treatment and relief of symptoms associated with irritable bowel syndrome (IBS):
abdominal pain, bowel disturbances and intestinal discomfort.
- for the treatment of symptoms related to functional disorders of the biliary tract. |
PubMed
Title | Date | PubMed |
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Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. | 2001 Jun |
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[Effects of dicetel on gastrointestinal motility and vegetative dysfunction in patients with duodenal ulcer]. | 2003 |
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Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. | 2004 |
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[New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis]. | 2004 |
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[Drug treatment of irritable bowel syndrome: an unmet need]. | 2007 Mar |
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[Pinaverium bromide-induced esophageal ulcerations]. | 2008 Jan-Feb |
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Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. | 2008 Nov 13 |
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Irritable bowel syndrome: a mild disorder; purely symptomatic treatment. | 2009 Apr |
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[Tiaohe Ganpi Hexin Decoction in treatment of irritable bowel syndrome with diarrhea: a randomized controlled trial]. | 2009 Sep |
Patents
Sample Use Guides
The usual adult dosage is 50 mg three times a day (total daily dose of 150 mg). The dosage may be increased up to a maximum of 100 mg taken three times a day (maximum total daily dose of 300 mg).
It is recommended that the tablet be taken with a glass of water during meals or snacks. The tablet should not be swallowed when in the lying position or just before bedtime.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11352508
In inflamed human colons, pinaverium (1 uM) display a significant higher efficacy than diltiazem or nicardipine to reduce cell contraction induced by CCK-8 or by KCl.
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QA03AX04
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C013199
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U2368VVE7O
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)