CHLORBENZOXAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H31ClN2O
Molecular Weight	435.001
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CN2CCN(CCOC(C3=CC=CC=C3)C4=CC=CC=C4Cl)CC2)C=CC=C1

InChI

InChIKey=VEVSKUJZSMGTMM-UHFFFAOYSA-N

InChI=1S/C27H31ClN2O/c1-22-9-5-6-12-24(22)21-30-17-15-29(16-18-30)19-20-31-27(23-10-3-2-4-11-23)25-13-7-8-14-26(25)28/h2-14,27H,15-21H2,1H3

HIDE SMILES / InChI

Molecular Formula	C27H31ClN2O
Molecular Weight	435.001
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4564225 | https://www.ncbi.nlm.nih.gov/pubmed/2902103 | https://www.ncbi.nlm.nih.gov/pubmed/14256886 | https://www.ncbi.nlm.nih.gov/pubmed/15445899 | https://www.ncbi.nlm.nih.gov/pubmed/14098333

Chlorbenzoxamine is an antimuscarinic agent used for the treatment of peptic ulcer disease and other functional gastrointestinal disorders. Chlorbenzoxamine, a structural analog of hydroxyzine, produces a unique antagonism of gastric ulceration induced in rats and dogs by various procedures. This effect is not accompanied by a significant gastric secretory depression or a reduction in gastric acid concentration. Chlorbenzoxamine does not show anticholinergic or antihistaminic activity in vitro but does produce a nonspecific depression of isolated smooth muscle. The antiulcer effect of chlorbenzoxamine in rats is abolished by hypophysectomy suggesting a central or endocrine mechanism of action.

Approval Year

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:52:37 UTC 2023` Edited by `admin` on `Sat Dec 16 15:52:37 UTC 2023`
Record UNII	N52918SLYN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORBENZOXAMINE

Official Name

English

Chlorbenzoxamine [WHO-DD]

Common Name

English

CHLORBENZOXAMINE [MI]

Common Name

English

chlorbenzoxamine [INN]

Common Name

English

1-(2-(O-CHLORO-.ALPHA.-PHENYLBENZYLOXY)ETHYL)-4-O-METHYLBENZYLPIPERAZINE

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA03AX03