POLDINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H26NO3
Molecular Weight	340.436
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

C[N+]1(C)CCCC1COC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=CQRKVVAGMJJJSR-UHFFFAOYSA-N

InChI=1S/C21H26NO3/c1-22(2)15-9-14-19(22)16-25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,9,14-16H2,1-2H3/q+1

HIDE SMILES / InChI

Molecular Formula	C21H25NO3
Molecular Weight	339.4281
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13769302

Poldine is an antimuscarinic drug, containing quaternary nitrogen. It is a selective inhibitor of gastric secretion. Administration of poldine leads to a 50% reduction of the volume and acid output of gastric juice without troublesome side-effects. Poldine was used for the treatment of gastric and duodenal ulcer under tradename "Nacton".

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
2 μg/mL EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/000629526690089X	12.5 mg/kg single, intravenous dose: 12.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		POLDINE blood	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
2.67 μg × min/mL EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/000629526690089X	12.5 mg/kg single, intravenous dose: 12.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		POLDINE blood	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
10 min EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/000629526690089X	12.5 mg/kg single, intravenous dose: 12.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		POLDINE blood	Rattus norvegicus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1WG8
BOC Sciences	545-80-2	https://www.bocsci.com/poldine-metilsulfate-cas-545-80-2-item-303559.html
ChemMol	99103832	http://www.chemmol.com/chemmol/99103832.html
LGC Standards	LGCFOR1911.00	https://www.lgcstandards.com/US/en/p/LGCFOR1911.00
MuseChem	R068198	https://www.musechem.com/product/R068198.html
NovoSeek	11017
PubChem	11017	https://pubchem.ncbi.nlm.nih.gov/compound/11017

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:57:34 GMT 2023` Edited by `admin` on `Fri Dec 15 17:57:34 GMT 2023`
Record UNII	8R92106W2F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POLDINE

Common Name

English

Poldine [WHO-DD]

Common Name

English

PYRROLIDINIUM, 2-(((HYDROXYDIPHENYLACETYL)OXY)METHYL)-1,1-DIMETHYL-

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

A03AB11