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Restrict the search for
tyrosine
to a specific field?
Status:
Investigational
Source:
NCT01561456: Phase 2 Interventional Completed Non-small-cell Lung Cancer
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Picropodophyllin (also known as picropodophyllotoxin (PPP)), an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Picropodophyllin possesses antineoplastic activity. PPP is currently tested as an orally administrated single agent treatment in an open-label combined Phase I/II clinical study in advanced cancer patients with solid tumors which progress in spite of several lines of treatment. In addition, it effectively inhibits rhambodmyosarcomas tumor proliferation and metastasis in vitro and in an animal model.
Status:
Investigational
Source:
USAN:THYROXINE I 131 [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Thyroxine I-131 is a radiolabeled thyroid hormone that has been studied as a diagnostic agent for thyroid cancer. In pharmacokinetic studies, Thyroxine I-131 shows broad tissue distribution and 99% of the ingested radiolabeled Thyroxine may be found in the skin, intestines, muscles, blood, bones, liver, and thyroid glands of rats.
Status:
Investigational
Source:
NCT00004828: Phase 1 Interventional Completed Tricuspid Atresia
(1994)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 131. Liothyronine involves many important metabolic functions and is essential to the proper development and differentiation of all cells. I131 liothyronine may be used in radiotherapy in thyroid cancers.
Status:
Investigational
Source:
USAN:THYROXINE I 125 [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Thyroxine I-125 is a radiolabeled thyroid hormone that has been used for diagnostics of thyroid disease. Thyroxine is the main hormone secreted into the bloodstream by the thyroid gland. Thyroxine plays vital roles in digestion, heart and muscle function, brain development and maintenance of bones. A thyroxine test measures the level of Thyroxine in the plasma and Thyroxine I-125 was used as a radioiodine-labeled tracer for this assay. Currently Thyroxine I-125 primary use as a tracer for binding assays and other radiometric biological studies.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Tolimidone, Lyn protein-tyrosine kinase stimulant, is in phase II clinical by Melior Discovery and Bukwang for the treatment of type 2 diabetes. It is also in phase II clinical by Pfizer for the treatment of ulcer. However, this research has been discontinued.
Status:
Investigational
Source:
NCT00979173: Phase 1 Interventional Completed Glioma
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
BMS 599626 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM. BMS-599626 is identified as an ATP-competitive inhibitor for HER1 and as an ATP-noncompetitive inhibitor for HER2. BMS-599626 inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2, including Sal2, BT474, N87, KPL-4, HCC202, HCC1954, HCC1419, AU565, ZR-75-30, MDA-MB-175, GEO, and PC9 cells. In a phase I trial of solid tumour patients receiving BMS 599626 no doselimiting toxicities were observed during the first cycle. Grade 1 or 2 drugrelated effects were reported and included diarrhoea, nausea, vomiting, rash, fatigue, musculoskeletal pain/cramp and cough. BristolMyers Squibb discontinued development of BMS 599626 for cancer in July 2015
Status:
Investigational
Source:
USAN:LIOTHYRONINE I 125 [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 125. Liothyronine involves many important metabolic functions and is essential to the proper development and differentiation of all cells. I-125 liothyronine may be used in radiotherapy in thyroid cancers. It was used for the thyroxine T4 determination in serum by competitive protein-binding analysis.
Status:
Investigational
Source:
USAN:DIOTYROSINE I 125 [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Diotyrosine I 125 is the diagnostic aid.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Sanguinarine is an extract of the bloodroot plant Sanguinaria canadensis, a member of the poppy family. It is an inhibitor of protein phosphatases PP1, PP2C and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and other enzymes. Sanguinarine exerts a protective effect in cerebral ischemia, and this effect is associated with its anti-inflammatory and anti-apoptotic properties. It was clinically tested as an agent against gingivitis and tooth plaques.
Status:
Designated
Source:
FDA ORPHAN DRUG:876122
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
