U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H12I3NO4
Molecular Weight 644.974
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIOTHYRONINE I-125

SMILES

N[C@@H](CC1=CC([125I])=C(OC2=CC=C(O)C([125I])=C2)C([125I])=C1)C(O)=O

InChI

InChIKey=AUYYCJSJGJYCDS-QBYPCAMJSA-N
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1/i16-2,17-2,18-2

HIDE SMILES / InChI
Molecular Formula C15H12I3NO4
Molecular Weight 644.974
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

A radioconjugate of synthetic active thyroid hormone, liothyronine (T3), labeled with Iodine 125. Liothyronine involves many important metabolic functions and is essential to the proper development and differentiation of all cells. I-125 liothyronine may be used in radiotherapy in thyroid cancers. It was used for the thyroxine T4 determination in serum by competitive protein-binding analysis.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Serum thyroxine resin uptake of liothyronine I 125, and free thyroxine index.
1970 Oct
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:24 UTC 2023
Edited
by admin
on Fri Dec 15 15:05:24 UTC 2023
Record UNII
S1UAI9MKMG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LIOTHYRONINE I-125
Common Name English
L-TYROSINE, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-, LABELED WITH IODINE-125
Common Name English
LIOTHYRONINE I 125
USAN  
USAN  
Official Name English
LIOTHYRONINE I 125 [USAN]
Common Name English
LIOTHYRONINE (125I)
Common Name English
L-ALANINE, 3-(4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL)-, LABELED WITH IODINE-125
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1446
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
NCI_THESAURUS C1553
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
Code System Code Type Description
CAS
24359-14-6
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
EPA CompTox
DTXSID30947217
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
NCI_THESAURUS
C80096
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
PUBCHEM
172996
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
FDA UNII
S1UAI9MKMG
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
ChEMBL
CHEMBL1544
Created by admin on Fri Dec 15 15:05:24 UTC 2023 , Edited by admin on Fri Dec 15 15:05:24 UTC 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966