TOLIMIDONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H10N2O2
Molecular Weight	202.2093
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(OC2=CNC(=O)N=C2)=CC=C1

InChI

InChIKey=HJQILFPVRNHTIG-UHFFFAOYSA-N

InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C11H10N2O2
Molecular Weight	202.2093
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.pharmacodia.com/yaodu/html/v1/chemicals/71def22ecb636394074c832abeed07a7.html
Curator's Comment: Description was created based on several sources, including http://adisinsight.springer.com/drugs/800023467 https://www.ncbi.nlm.nih.gov/pubmed/22431203

Tolimidone, Lyn protein-tyrosine kinase stimulant, is in phase II clinical by Melior Discovery and Bukwang for the treatment of type 2 diabetes. It is also in phase II clinical by Pfizer for the treatment of ulcer. However, this research has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosine-protein kinase Lyn 4 Target ID: CHEMBL3905 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22473614	Activator 1447		63.0 nM [EC50]
Insulin receptor 13 Target ID: CHEMBL3187 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22431203	Activator 1447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Type 2 diabetes mellitus 262 Sources: http://adisinsight.springer.com/drugs/800023467	Primary		Phase II 1147	Unknown Approved Use Unknown

T_1/2

Value	Dose	Co-administered	Analyte	Population
0.61 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34832978/	100 mg 1 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:		TOLIMIDONE plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P00CA6M	https://www.1pchem.com/search?query=1P00CA6M
AChemBlock	O32688	http://www.achemblock.com/catalogsearch/result/?q=O32688
AK Scientific	SYN5050	https://aksci.com/item_detail.php?cat=SYN5050
AOBIOUS INC	AOB1019	http://aobious.com/aobious/search?search_query=AOB1019
ApexBio Technology	B5648	https://www.apexbt.com/catalogsearch/result/?q=B5648
AstaTech	41433	http://astatechinc.com/CPSResult.php?CRNO=41433
Axon MedChem	1941	https://www.axonmedchem.com/product/1941
BOC Sciences	41964-07-2	http://www.bocsci.com/description.asp?cas=41964-07-2
Capot Chemical	25852	https://www.capotchem.com/search.do?q=25852
Cayman Chemical	21496	http://www.caymanchem.com/app/template/Product.vm/catalog/21496
Chem Scene	CS-7936	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-7936
Chemik	CHH08001	http://www.chemik.com/cgi/search-en.cgi?f=product_en+product_en1+company_en_1_&t=product_en7&w=product_en&terms=CHH08001
ChemShuttle	100568	https://www.chemshuttle.com/catalogsearch/result/?q=100568
Chemspace	CSC009998454	https://chem-space.com/CSC009998454
Chemspace	CSC052750081	https://chem-space.com/CSC052750081
eMolecules	43217079	https://orderbb.emolecules.com/search/#?query=43217079
Enamine	BBV-45114518	http://www.enaminestore.com/catalog/BBV-45114518
Enamine	BBV-78238145	http://www.enaminestore.com/catalog/BBV-78238145
Enamine	EN300-1599855	https://www.enaminestore.com/catalog/EN300-1599855
Excenen	EX-A1338	http://www.excenen.com/searchresultlist.php?id=EX-A1338
Hairui	HR146239	http://www.hairuichem.com/en/product/search.do?q=HR146239
KeyOrganics	AS-16416	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-16416
Lab Network	LN01313524	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01313524
Matrix Scientific	131518	http://www.matrixscientific.com/131518.html
mcule	MCULE-1695512072	https://mcule.com/MCULE-1695512072/
MedChem Express	HY-59047	https://www.medchemexpress.com/search.html?q=HY-59047&ft=&fa=&fp=
Molnova	M18535	https://www.molnova.com/en/serch-list.html?keywords=M18535
MolPort	MolPort-000-884-778	https://www.molport.com/shop/molecule-link/MolPort-000-884-778
MuseChem	R039560	https://www.musechem.com/product/R039560.html
ShangHai Biochempartner	BCP06813	http://www.biochempartner.com/search_BCP06813
TargetMol	T6896	https://www.targetmol.com/search?keyword=T6896
Tocris	4582	https://www.tocris.com/search.php?Type=QuickSearch&Value=4582
Toronto Research Chemicals	T535340	https://www.trc-canada.com/product-detail/?CatNum=T535340
Wonderchem	WD09T23	http://www.wonder-chem.com/search.html?text=WD09T23

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Mice - A single administration of MLR-1023 (Tolimidone) elicited a reduction in blood glucose levels, with a maximal response produced by a dose level of 30 mg/kg.

Route of Administration: Oral

In Vitro Use Guide

Incubation of Tolimidone (10 uM) with Lyn kinase elicited a repeatable 50% increase in enzyme activity.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:06 GMT 2025`
Record UNII	MU3JD8E9IS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CP-26,154

Preferred Name

English

TOLIMIDONE

Official Name

English

CP-26154

Code

English

2(1H)-PYRIMIDINONE, 5-(3-METHYLPHENOXY)-

Systematic Name

English

TOLIMIDONE [USAN]

Common Name

English

tolimidone [INN]

Common Name

English

5-(3-METHYLPHENOXY)-2(1H)-PYRIMIDINONE

Systematic Name

English

Tolimidone [WHO-DD]

Common Name

English

MLR-1023

Code

English

NSC-314335

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29711