U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C11H10N2O2
Molecular Weight 202.2093
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOLIMIDONE

SMILES

CC1=CC=CC(OC2=CNC(=O)N=C2)=C1

InChI

InChIKey=HJQILFPVRNHTIG-UHFFFAOYSA-N
InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

HIDE SMILES / InChI

Molecular Formula C11H10N2O2
Molecular Weight 202.2093
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tolimidone, Lyn protein-tyrosine kinase stimulant, is in phase II clinical by Melior Discovery and Bukwang for the treatment of type 2 diabetes. It is also in phase II clinical by Pfizer for the treatment of ulcer. However, this research has been discontinued.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
63.0 nM [EC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Mice - A single administration of MLR-1023 (Tolimidone) elicited a reduction in blood glucose levels, with a maximal response produced by a dose level of 30 mg/kg.
Route of Administration: Oral
In Vitro Use Guide
Incubation of Tolimidone (10 uM) with Lyn kinase elicited a repeatable 50% increase in enzyme activity.
Substance Class Chemical
Record UNII
MU3JD8E9IS
Record Status Validated (UNII)
Record Version