U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 311 - 320 of 12523 results

Status:
Investigational
Source:
NCT00358488: Phase 2 Interventional Completed Pulmonary Disease, Chronic Obstructive
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Milveterol (also known as GSK159797) was developed as a longer-acting beta2 adrenoceptor agonist for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Milveterol completed phase II clinical trials for asthmatic subjects. However further development of the drug was discontinued.
Status:
Investigational
Source:
INN:peliglitazar [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Peliglitazar (also known as BMS 426707-01), a dual α/γ peroxisome proliferator-activated receptor agonist, has been studied in phase I/II clinical trial in patients with type 2 diabetes mellitus. However, this study was discontinued.
Status:
Investigational
Source:
INN:modoflaner [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
JAN:INAPERISONE HYDROCHLORIDE [JAN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Inaperisone is a pyrrolidinopropiophenone derivative patented by Japanese pharmaceutical company Hokuriku Pharmaceutical Co. as muscle-relaxant and antispasmodic agent.
Status:
Investigational
Source:
INN:dopamantine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dopamantine is the adamantine derivative. It combined elements of both amantadine and dopamine in its structure, shares some pharmacological effects of amantadine. Dopamantine is the anti-Parkinson drug, which has passed clinical trials. Dopamantine showed a high activity against Plasmodium berghei parasites that cause malaria.
Status:
Investigational
Source:
INN:mepiprazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Mepiprazole is a psychotropic pyrazole derivative. Mepiprazole is a serotonin reuptake inhibitor and adrenolytic. In clinical studies, it demonstrated anxiolytic properties.
Status:
Investigational
Source:
NCT00639249: Phase 2 Interventional Completed Ischemic Stroke
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Cutamesine, an agonsit of brain sigma 1 receptors, was developed by Santen Pharmaceutical for the treatment of cognitive diseases. The drug was tested in phase II in patients with major depressive disorders and for recovery of patients with stroke, however its development was terminated for the given conditions. Currently M's science corporation is developing cutamesine for Amyotrophic lateral sclerosis and Retinitis pigmentosa as more suitable target diseases.
Status:
Investigational
Source:
INN:dasantafil [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Schering published xanthine PDE5 inhibitors with amino substituents in the imidazole 2-position, such as Dasantafil. Dasantafil, also known as SCH-446132, is a PDE5A inhibitor potentially for the treatment of erectile dysfunction. It had been in phase II clinical trials but there is no report for this compound recently.
Status:
Investigational
Source:
INN:etoxeridine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Etoxeridine (Carbetidine or Wy2039), a piperidine derivative, is a narcotic analgetic.
Status:
Investigational
Source:
INN:droxacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Droxacin is quinolone antibiotic. It is topoisomerase inhibitor.