MEPIPRAZOLE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H21ClN4
Molecular Weight	304.818
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEPIPRAZOLE

Structure Search

SMILES

CC1=CC(CCN2CCN(CC2)C3=CC=CC(Cl)=C3)=NN1

InChI

InChIKey=DOTIMEKVTCOGED-UHFFFAOYSA-N

InChI=1S/C16H21ClN4/c1-13-11-15(19-18-13)5-6-20-7-9-21(10-8-20)16-4-2-3-14(17)12-16/h2-4,11-12H,5-10H2,1H3,(H,18,19)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/989382 | https://www.ncbi.nlm.nih.gov/pubmed/9660 | https://www.ncbi.nlm.nih.gov/pubmed/7255266 | https://www.ncbi.nlm.nih.gov/pubmed/1095510 | https://www.ncbi.nlm.nih.gov/pubmed/769484

Mepiprazole is a psychotropic pyrazole derivative. Mepiprazole is a serotonin reuptake inhibitor and adrenolytic. In clinical studies, it demonstrated anxiolytic properties.

CNS Activity

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety].	1976	1052713
Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes.	1976 Aug 17	9660
1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.	1982 Oct	6128394

Patents

Patents

Name

Type

Language

MEPIPRAZOLE

Official Name

English

1-(M-CHLOROPHENYL)-4-(2-(5-METHYLPYRAZOL-3-YL)ETHYL)PIPERAZINE

Systematic Name

English

EMD-16923

Code

English

MEPIPRAZOLE [MI]

Common Name

English

mepiprazole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

Code System Code Type Description

PUBCHEM

71897

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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DRUG CENTRAL

5097

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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CAS

20326-12-9

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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EPA CompTox

DTXSID30174223

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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MERCK INDEX

m306

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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Merck Index

ChEMBL

CHEMBL2106537

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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FDA UNII

977BAL0NR7

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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EVMPD

SUB08751MIG

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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NCI_THESAURUS

C66092

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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MESH

C008351

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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WIKIPEDIA

Mepiprazole

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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DRUG BANK

DB09197

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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INN

2954

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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SMS_ID

100000081497

Created by admin on Sat Dec 16 16:52:14 GMT 2023 , Edited by admin on Sat Dec 16 16:52:14 GMT 2023

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ACTIVE MOIETY


					977BAL0NR7

METABOLITE ACTIVE (PARENT)


					REY0CNO998

M-CHLOROPHENYLPIPERAZINE

SALT/SOLVATE (PARENT)


					TN5WJ92YGP

MEPIPRAZOLE DIHYDROCHLORIDE