DOPAMANTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25NO3
Molecular Weight	315.4067
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(O)C=C(CCNC(=O)C23CC4CC(CC(C4)C2)C3)C=C1

InChI

InChIKey=ZWKFENYDXISLGK-UHFFFAOYSA-N

InChI=1S/C19H25NO3/c21-16-2-1-12(8-17(16)22)3-4-20-18(23)19-9-13-5-14(10-19)7-15(6-13)11-19/h1-2,8,13-15,21-22H,3-7,9-11H2,(H,20,23)

HIDE SMILES / InChI

Molecular Formula	C19H25NO3
Molecular Weight	315.4067
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1134/S1070428017120028 | https://www.ncbi.nlm.nih.gov/pubmed/20858176 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 466, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | DOI: 10.1016/S0065-7743(08)61424-4

Dopamantine is the adamantine derivative. It combined elements of both amantadine and dopamine in its structure, shares some pharmacological effects of amantadine. Dopamantine is the anti-Parkinson drug, which has passed clinical trials. Dopamantine showed a high activity against Plasmodium berghei parasites that cause malaria.

Approval Year

PubMed

Title	Date	PubMed
Use of the adamantane structure in medicinal chemistry.	2010	20858176

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:52:19 GMT 2023` Edited by `admin` on `Sat Dec 16 16:52:19 GMT 2023`
Record UNII	7EZN745FXZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DOPAMANTINE

Official Name

English

N-(3,4-Dihydroxyphenethyl)-1-adamantanecarboxamide

Systematic Name

English

N-ADAMANTANOYL DOPAMINE [INCI]

Common Name

English

SCH-15507

Code

English

SCH 15507

Code

English

NSC-172619

Code

English

TRICYCLO(3,3,1,1(SUP 3,7)DECANE-1-CARBOXAMIDE, N-(2-(3,4-DIHYDROXYPHENYL)ETHYL)-

Common Name

English

N-ADAMANTANOYL DOPAMINE

Official Name

English

DOPAMANTINE [USAN]

Common Name

English

dopamantine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149