MILVETEROL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H29N3O4
Molecular Weight	435.5155
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@@H](CNCCC1=CC=C(NC[C@H](O)C2=CC=CC=C2)C=C1)C3=CC=C(O)C(NC=O)=C3

InChI

InChIKey=BMKINZUHKYLSKI-DQEYMECFSA-N

InChI=1S/C25H29N3O4/c29-17-28-22-14-20(8-11-23(22)30)24(31)15-26-13-12-18-6-9-21(10-7-18)27-16-25(32)19-4-2-1-3-5-19/h1-11,14,17,24-27,30-32H,12-13,15-16H2,(H,28,29)/t24-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H29N3O4
Molecular Weight	435.5155
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT00358488 | https://adisinsight.springer.com/drugs/800020024

Milveterol (also known as GSK159797) was developed as a longer-acting beta2 adrenoceptor agonist for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Milveterol completed phase II clinical trials for asthmatic subjects. However further development of the drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Novel bronchodilators in asthma.	2010 Jan	19816179
A multivalent approach to the discovery of long-acting β(2)-adrenoceptor agonists for the treatment of asthma and COPD.	2012 Jan 15	22178551
Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends.	2015 May 28	25587755

Patents

Sample Use Guides

In Vivo Use Guide

GSK159797 (10, 15, and 20mcg) following dosing for 14 days

Route of Administration: Respiratory

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:00 UTC 2023` Edited by `admin` on `Sat Dec 16 16:55:00 UTC 2023`
Record UNII	LGY1VQ9622
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MILVETEROL

Official Name

English

milveterol [INN]

Common Name

English

GSK-159797

Code

English

FORMAMIDE, N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-((2-(4-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)PHENYL)ETHYL)AMINO)ETHYL)PHENYL)-

Systematic Name

English

GSK159797

Code

English

N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-((2-(4-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)PHENYL)ETHYL)AMINO)ETHYL)PHENYL)FORMAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149