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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H29N3O4.ClH
Molecular Weight 471.976
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MILVETEROL HYDROCHLORIDE

SMILES

Cl.O[C@@H](CNC1=CC=C(CCNC[C@H](O)C2=CC=C(O)C(NC=O)=C2)C=C1)C3=CC=CC=C3

InChI

InChIKey=QQPHRRSYJMOQOC-DKIIUIKKSA-N
InChI=1S/C25H29N3O4.ClH/c29-17-28-22-14-20(8-11-23(22)30)24(31)15-26-13-12-18-6-9-21(10-7-18)27-16-25(32)19-4-2-1-3-5-19;/h1-11,14,17,24-27,30-32H,12-13,15-16H2,(H,28,29);1H/t24-,25-;/m0./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C25H29N3O4
Molecular Weight 435.5155
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Milveterol (also known as GSK159797) was developed as a longer-acting beta2 adrenoceptor agonist for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Milveterol completed phase II clinical trials for asthmatic subjects. However further development of the drug was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
A multivalent approach to the discovery of long-acting β(2)-adrenoceptor agonists for the treatment of asthma and COPD.
2012 Jan 15
Patents

Sample Use Guides

GSK159797 (10, 15, and 20mcg) following dosing for 14 days
Route of Administration: Respiratory
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:41:13 GMT 2023
Edited
by admin
on Fri Dec 15 15:41:13 GMT 2023
Record UNII
1D1MD355SJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MILVETEROL HYDROCHLORIDE
USAN  
USAN  
Official Name English
GSK-159797C
Code English
MILVETEROL HCL
Common Name English
N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[2-[4-[[(2R)-2-hydroxy-2-phenylethyl]amino]phenyl]ethyl]amino]ethyl]phenyl]formamide monohydrochloride
Systematic Name English
GSK159797C
Code English
MILVETEROL HYDROCHLORIDE [USAN]
Common Name English
FORMAMIDE,N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-((2-(4-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)PHENYL)ETHYL)AMINO)ETHYL)PHENYL)-, MONOHYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C48149
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1940832
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
FDA UNII
1D1MD355SJ
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
NCI_THESAURUS
C77936
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID50230335
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
CAS
804518-03-4
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
PUBCHEM
11225217
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
USAN
SS-26
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
SMS_ID
300000044610
Created by admin on Fri Dec 15 15:41:13 GMT 2023 , Edited by admin on Fri Dec 15 15:41:13 GMT 2023
PRIMARY
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