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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H28BrN5O5
Molecular Weight 522.392
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DASANTAFIL

SMILES

CCN1C(=O)N(CCO)C2=C(N(CC3=CC(Br)=C(OC)C=C3)C(N[C@@H]4CCC[C@H]4O)=N2)C1=O

InChI

InChIKey=RCJYGWGQCPDYSL-HZPDHXFCSA-N
InChI=1S/C22H28BrN5O5/c1-3-26-20(31)18-19(27(9-10-29)22(26)32)25-21(24-15-5-4-6-16(15)30)28(18)12-13-7-8-17(33-2)14(23)11-13/h7-8,11,15-16,29-30H,3-6,9-10,12H2,1-2H3,(H,24,25)/t15-,16-/m1/s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.pharmacodia.com/yaodu/html/v1/chemicals/4b58db5ec33af76c6d9b968cf2c633b1.html | http://adisinsight.springer.com/drugs/800018967

Schering published xanthine PDE5 inhibitors with amino substituents in the imidazole 2-position, such as Dasantafil. Dasantafil, also known as SCH-446132, is a PDE5A inhibitor potentially for the treatment of erectile dysfunction. It had been in phase II clinical trials but there is no report for this compound recently.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
DASANTAFIL
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
1H-PURINE-2,6-DIONE, 7-((3-BROMO-4-METHOXYPHENYL)METHYL)-1-ETHYL-3,7-DIHYDRO-8-(((1R,2R)-2-HYDROXYCYCLOPENTYL)AMINO)-3-(2-HYDROXYETHYL)
Common Name English
SCH446132
Code English
DASANTAFIL [USAN]
Common Name English
SCH-446132
Code English
dasantafil [INN]
Common Name English
7-(3-Bromo-4-methoxybenzyl)-1-ethyl-8-[[(1R,2R)-2-hydroxycyclopentyl]amino]-3-(2-hydroxyethyl)-3,7-dihydro-1H-purine-2,6-dione
Systematic Name English
Dasantafil [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2127
Created by admin on Sat Dec 16 16:47:24 GMT 2023 , Edited by admin on Sat Dec 16 16:47:24 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2107326
Created by admin on Sat Dec 16 16:47:23 GMT 2023 , Edited by admin on Sat Dec 16 16:47:23 GMT 2023
PRIMARY
PUBCHEM
9871410
Created by admin on Sat Dec 16 16:47:24 GMT 2023 , Edited by admin on Sat Dec 16 16:47:24 GMT 2023
PRIMARY
SMS_ID
300000034103
Created by admin on Sat Dec 16 16:47:24 GMT 2023 , Edited by admin on Sat Dec 16 16:47:24 GMT 2023
PRIMARY
NCI_THESAURUS
C76888
Created by admin on Sat Dec 16 16:47:24 GMT 2023 , Edited by admin on Sat Dec 16 16:47:24 GMT 2023
PRIMARY
INN
8485
Created by admin on Sat Dec 16 16:47:23 GMT 2023 , Edited by admin on Sat Dec 16 16:47:23 GMT 2023
PRIMARY
CAS
569351-91-3
Created by admin on Sat Dec 16 16:47:23 GMT 2023 , Edited by admin on Sat Dec 16 16:47:23 GMT 2023
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USAN
PP-55
Created by admin on Sat Dec 16 16:47:24 GMT 2023 , Edited by admin on Sat Dec 16 16:47:24 GMT 2023
PRIMARY
FDA UNII
48P711MI2G
Created by admin on Sat Dec 16 16:47:23 GMT 2023 , Edited by admin on Sat Dec 16 16:47:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID30205480
Created by admin on Sat Dec 16 16:47:23 GMT 2023 , Edited by admin on Sat Dec 16 16:47:23 GMT 2023
PRIMARY