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Restrict the search for
methyl salicylate
to a specific field?
Class (Stereo):
CHEMICAL (MIXED)
Odalprofen was used as an analgesic. Information about the current use of this compound is not available.
Status:
Investigational
Source:
JAN:LASCUFLOXACIN HYDROCHLORIDE [JAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.
Status:
Investigational
Source:
NCT02945774: Not Applicable Interventional Recruiting Frontotemporal Dementia
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03820245: Not Applicable Interventional Completed Oxidative Stress
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Xorphanol (also known as TR5379M) is a full κ-opioid receptor agonist and is a partial agonist at μ opioid receptor. Clinically, xorphanol was studied as an orally active analgesic that provided effective pain relief but showed low physical dependence liability. Further development of this drug was discontinued.
Status:
Investigational
Source:
NCT00745108: Phase 3 Interventional Completed Postmenopausal Women
(2001)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Cerium is a grey metal. It is little used because it tarnishes easily, reacts with water and burns when heated. Cerium is the major component of mischmetal alloy (just under 50%). The best-known use for this alloy is in ‘flints’ for cigarette lighters. This is because cerium will make sparks when struck. The only other element that does this is iron. Cerium(Ill) oxide has uses as a catalyst. It is used in the inside walls of self-cleaning ovens to prevent the build-up of cooking residues. It is also used in catalytic converters. Cerium(III) oxide nanoparticles are being studied as an additive for diesel fuel to help it burn more completely and reduce exhaust emissions.
Cerium sulfide is a non-toxic compound that is a rich red color. It is used as a pigment. Cerium is also used in flat-screen TVs, low-energy light bulbs and floodlights. A cerium oxide nanoparticles (nanoceria) has a wide range of applications in different fields, especially biomedical division. As a matter of concern, it has a major impact on the human health and environment. Nanoceria was toxic towards human cancer cell lines. They can lead to the release of free radicals and oxidative stress ultimately leading to cell membrane damage and lipid peroxidation. However, ROS mediated DNA damage and cell cycle arrest. Finally, nanoceria can be used for several biomedical applications mostly for ROS related diseases like cardiac diseases, Alzheimer’s disease, and cancer. So, the ROS scavenging nanoceria can be considered as an alternative therapy for oxidative stress and several diseases and disorders.
Status:
Investigational
Source:
INN:clonitazene [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Clonitazene is a synthetic opioid analgesic, structurally related to etonitazene. In the USA clonitazene is a schedule I narcotic controlled substance.
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Imiloxan is a highly selective alpha2B adrenoceptor antagonist and was developed for depression in the 1980s. In Phase 1 clinical trials imiloxan dosing led to hypersensitivity reactions; the molecule's development was discontinued.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Lergotrile is an ergot alkaloid clinically effective in the treatment of Parkinson’s disease. The in vivo dopaminergic effects of lergotrile are similar to those produced by the direct acting dopaminergic agonists apomorphine or L-DOPA. Like apomorphine or L-DOPA, lergotrile decreases prolactin secretion, produces stereotyped behavior in intact rats, and causes contralateral rotation in rats with uniIateral 6-hydroxydopamine lesions of substantia nigra. However, unlike apomorphine or L-DOPA, lergotrile does not activate dopamine sensitive adenylate cyclase in vitro. Side effects of lergotrile included exacerbation of hallucinations, dyskinesias, hypotension, and alterations in liver function tests. Although lergotrile, when added to levodopa, has a definite antiparkinsonian effect, the incidence of adverse effects, particularly hepatotoxicity, makes it unlikely that this ergot alkaloid will become widely available for the treatment of Parkinson’s disease.
Status:
Investigational
Source:
INN:leiopyrrole [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
LEIOPYRROLE is an antispasmodic agent.
