LASCUFLOXACIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24F3N3O4
Molecular Weight	439.4282
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C2N(CCF)C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@@H](F)[C@@H](CNC4CC4)C3

InChI

InChIKey=ZFIOCUITTUUVPV-MEDUHNTESA-N

InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H24F3N3O4
Molecular Weight	439.4282
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28320717 | https://www.ncbi.nlm.nih.gov/pubmed/30114441 | https://adisinsight.springer.com/drugs/800035339

LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.

Originator

Approval Year

PubMed

Title	Date	PubMed
In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).	2017 Jun	28320717
Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers.	2018 Apr	29339391
In vitro activity of lascufloxacin, a novel fluoroquinolone antibacterial agent, against various clinical isolates of anaerobes and Streptococcus anginosus group.	2018 Dec	30114441
In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.	2019 Apr	30718243

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:41:47 UTC 2023` Edited by `admin` on `Fri Dec 15 16:41:47 UTC 2023`
Record UNII	55MOB566V7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LASCUFLOXACIN

Official Name

English

7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUOROPYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUOROETHYL)-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Systematic Name

English

3-QUINOLINECARBOXYLIC ACID, 7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUORO-1-PYRROLIDINYL)-6-FLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-8-METHOXY-4-OXO-

Systematic Name

English

Lascufloxacin [WHO-DD]

Common Name

English

lascufloxacin [INN]

Common Name

English

Code System Code Type Description

DRUG CENTRAL

5370