LASCUFLOXACIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24F3N3O4
Molecular Weight	439.4282
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(N2C[C@@H](F)[C@@H](CNC3CC3)C2)C(F)=CC4=C1N(CCF)C=C(C(O)=O)C4=O

InChI

InChIKey=ZFIOCUITTUUVPV-MEDUHNTESA-N

InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H24F3N3O4
Molecular Weight	439.4282
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28320717 | https://www.ncbi.nlm.nih.gov/pubmed/30114441 | https://adisinsight.springer.com/drugs/800035339

LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.

Originator

Approval Year

PubMed

Title	Date	PubMed
In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.	2019-04	30718243
In vitro activity of lascufloxacin, a novel fluoroquinolone antibacterial agent, against various clinical isolates of anaerobes and Streptococcus anginosus group.	2018-12	30114441
Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers.	2018-04	29339391
In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).	2017-06	28320717

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:34:50 GMT 2025` Edited by `admin` on `Mon Mar 31 18:34:50 GMT 2025`
Record UNII	55MOB566V7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

lascufloxacin [INN]

Preferred Name

English

LASCUFLOXACIN

Official Name

English

7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUOROPYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUOROETHYL)-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Systematic Name

English

3-QUINOLINECARBOXYLIC ACID, 7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUORO-1-PYRROLIDINYL)-6-FLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-8-METHOXY-4-OXO-

Systematic Name

English

Lascufloxacin [WHO-DD]

Common Name

English

Code System Code Type Description

DRUG CENTRAL

5370