U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H24F3N3O4.CH4O3S
Molecular Weight 535.534
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LASCUFLOXACIN MESYLATE

SMILES

CS(O)(=O)=O.COC1=C2N(CCF)C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@@H](F)[C@@H](CNC4CC4)C3

InChI

InChIKey=LLRDGHMAFPAJJT-DFIJPDEKSA-N
InChI=1S/C21H24F3N3O4.CH4O3S/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12;1-5(2,3)4/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30);1H3,(H,2,3,4)/t11-,16+;/m0./s1

HIDE SMILES / InChI
Molecular Formula CH4O3S
Molecular Weight 96.106
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C21H24F3N3O4
Molecular Weight 439.4282
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).
2017 Jun
Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers.
2018 Apr
In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.
2019 Apr
Substance Class Chemical
Created
by admin
on Sat Dec 16 07:42:57 UTC 2023
Edited
by admin
on Sat Dec 16 07:42:57 UTC 2023
Record UNII
D25Q04AD78
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LASCUFLOXACIN MESYLATE
Common Name English
3-QUINOLINECARBOXYLIC ACID, 7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUORO-1-PYRROLIDINYL)-6-FLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-8-METHOXY-4-OXO-, METHANESULFONATE (1:1)
Systematic Name English
LASCUFLOXACIN MESILATE
WHO-DD  
Common Name English
Lascufloxacin mesilate [WHO-DD]
Common Name English
Code System Code Type Description
CAS
1433857-41-0
Created by admin on Sat Dec 16 07:42:57 UTC 2023 , Edited by admin on Sat Dec 16 07:42:57 UTC 2023
PRIMARY
FDA UNII
D25Q04AD78
Created by admin on Sat Dec 16 07:42:57 UTC 2023 , Edited by admin on Sat Dec 16 07:42:57 UTC 2023
PRIMARY
PUBCHEM
71569948
Created by admin on Sat Dec 16 07:42:57 UTC 2023 , Edited by admin on Sat Dec 16 07:42:57 UTC 2023
PRIMARY
Related Record Type Details
Structure of LASCUFLOXACIN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of LASCUFLOXACIN
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966