LASCUFLOXACIN HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24F3N3O4.ClH
Molecular Weight	475.889
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LASCUFLOXACIN HYDROCHLORIDE

Structure Search

SMILES

Cl.COC1=C(N2C[C@@H](F)[C@@H](CNC3CC3)C2)C(F)=CC4=C1N(CCF)C=C(C(O)=O)C4=O

InChI

InChIKey=YQHZQIJEMFMUGH-DFIJPDEKSA-N

InChI=1S/C21H24F3N3O4.ClH/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12;/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30);1H/t11-,16+;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C21H24F3N3O4
Molecular Weight	439.4282
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28320717 | https://www.ncbi.nlm.nih.gov/pubmed/30114441 | https://adisinsight.springer.com/drugs/800035339

LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.

Originator

Approval Year

PubMed

Title	Date	PubMed
In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.	2019-04	30718243
In vitro activity of lascufloxacin, a novel fluoroquinolone antibacterial agent, against various clinical isolates of anaerobes and Streptococcus anginosus group.	2018-12	30114441
Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers.	2018-04	29339391
In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).	2017-06	28320717

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:40:04 GMT 2025` Edited by `admin` on `Mon Mar 31 21:40:04 GMT 2025`
Record UNII	8GYE97TPKI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LASCUFLOXACIN HYDROCHLORIDE

Common Name

English

3-QUINOLINECARBOXYLIC ACID, 7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUORO-1-PYRROLIDINYL)-6-FLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-8-METHOXY-4-OXO-, HYDROCHLORIDE (1:1)

Preferred Name

English

LASCUFLOXACIN HYDROCHLORIDE [JAN]

Common Name

English

Lascufloxacin hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

300000032940

Created by admin on Mon Mar 31 21:40:04 GMT 2025 , Edited by admin on Mon Mar 31 21:40:04 GMT 2025

PRIMARY

FDA UNII

8GYE97TPKI

Created by admin on Mon Mar 31 21:40:04 GMT 2025 , Edited by admin on Mon Mar 31 21:40:04 GMT 2025

PRIMARY

PUBCHEM

71528767

Created by admin on Mon Mar 31 21:40:04 GMT 2025 , Edited by admin on Mon Mar 31 21:40:04 GMT 2025

PRIMARY

CAS

1433857-09-0

Created by admin on Mon Mar 31 21:40:04 GMT 2025 , Edited by admin on Mon Mar 31 21:40:04 GMT 2025

PRIMARY

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LASCUFLOXACIN

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Amount:

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					55MOB566V7

LASCUFLOXACIN

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/28320717 | https://www.ncbi.nlm.nih.gov/pubmed/30114441 | https://adisinsight.springer.com/drugs/800035339

Originator

Approval Year

PubMed

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28320717 | https://www.ncbi.nlm.nih.gov/pubmed/30114441 | https://adisinsight.springer.com/drugs/800035339