U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H24F3N3O4
Molecular Weight 439.4282
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LASCUFLOXACIN

SMILES

COC1=C2N(CCF)C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@@H](F)[C@@H](CNC4CC4)C3

InChI

InChIKey=ZFIOCUITTUUVPV-MEDUHNTESA-N
InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1

HIDE SMILES / InChI
LASCUFLOXACIN, a fluoroquinolone derivative, is an antibacterial agent with a broad spectrum of activity against various clinical isolates. It is under development for the treatment of respiratory tract infections and community-acquired pneumonia.

Approval Year

PubMed

PubMed

TitleDatePubMed
In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).
2017 Jun
Intrapulmonary Pharmacokinetics of Lascufloxacin in Healthy Adult Volunteers.
2018 Apr
In vitro activity of lascufloxacin, a novel fluoroquinolone antibacterial agent, against various clinical isolates of anaerobes and Streptococcus anginosus group.
2018 Dec
In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.
2019 Apr
Name Type Language
LASCUFLOXACIN
INN   WHO-DD  
INN  
Official Name English
7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUOROPYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUOROETHYL)-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
Systematic Name English
3-QUINOLINECARBOXYLIC ACID, 7-((3S,4S)-3-((CYCLOPROPYLAMINO)METHYL)-4-FLUORO-1-PYRROLIDINYL)-6-FLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-8-METHOXY-4-OXO-
Systematic Name English
Lascufloxacin [WHO-DD]
Common Name English
lascufloxacin [INN]
Common Name English
Code System Code Type Description
DRUG CENTRAL
5370
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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WIKIPEDIA
Lascufloxacin
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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SMS_ID
300000019094
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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PUBCHEM
71528768
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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INN
10017
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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EPA CompTox
DTXSID001336967
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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CAS
848416-07-9
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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NCI_THESAURUS
C166817
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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FDA UNII
55MOB566V7
Created by admin on Fri Dec 15 16:41:47 GMT 2023 , Edited by admin on Fri Dec 15 16:41:47 GMT 2023
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