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Restrict the search for
methyl salicylate
to a specific field?
Class (Stereo):
CHEMICAL (MIXED)
Mexiprostil (also known as MDL 646), a synthetic prostaglandin was developed as a potent antiulcer agent. Experiments on animals have revealed that this drug possessed gastric protection, diarrheogenic and arterial hypotensive effects. The supposed local activity coupled with the antisecretory effects and the good tolerability made it interesting to test mexiprostil as an anti-ulcer agent in man. However, information about the further development of the drug is not available.
Status:
Investigational
Source:
NCT04028492: Phase 3 Interventional Recruiting Idiopathic Gastroparesis
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Tradipitant is a neurokinin 1 receptor antagonist. The dose of 50 mg of tradipitant given orally for 4 weeks was not superior to placebo in reducing itch intensity in patients with atopic dermatitis. However, in a subsequent study, in which a higher dose (85 mg) was administered for 8 weeks, significant antipruritic effect compared with placebo was recorded. Tradipitant is in phase III clinical trial for the treatment of atopic dermatitis and gastroparesis. Vanda Pharmaceuticals plans a phase III trial in Motion Sickness in 2019.
Status:
Investigational
Source:
NCT00830154: Phase 2/Phase 3 Interventional Completed Stuttering
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Pagoclone is an anxiolytic agent from the cyclopyrrolone family, related to better-known drugs such as the sleeping medication zopiclone. It binds with the roughly equivalent high affinity (0.7–9.1 nM) to the benzodiazepine binding site of human GABAA receptors containing either a α1, α2, α3 or α5 subunit. It is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containing a α3 subunit. Pagoclone produces anxiolytic effects with little sedative or amnestic actions at low doses.
Status:
Investigational
Source:
NCT00003021: Phase 1 Interventional Completed Unspecified Adult Solid Tumor, Protocol Specific
(1997)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Bizelesin (previously known as U-77779 or NSC 615291), a cyclopropylpyrroloindole antitumor agent acts as a bifunctional alkylating agent and produces DNA interstrand cross-links. This drug participated in phase I clinical trials in patients with advanced solid malignancies, however further development was discontinued.
Class (Stereo):
CHEMICAL (RACEMIC)
Acridorex (BS 7573a) is an anorectic agent.
Status:
Investigational
Source:
INN:mecloxamine [INN]
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Mecloxamine is an anticholinergic exerting sedative and hypnotic activity.
Status:
Investigational
Source:
INN:pyrophendane [INN]
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Pyrophenindane is pyrrolidylmethyl-substituted arylindan patented by Mead Johnson & Co. as antispasmodic agent. Pyrophenindane have potent activity in the prevention of reserpine-induced ptosis in mice, a test for antidepressant activity.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Indimilast is dioxodihydropyridopyrimidine derivative patented by global pharmaceutical company AstraZeneca as phosphodiesterase IV inhibitor. Indimilast modulates lung inflammation and causes bronchodilation by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Indimilast is potentially useful in chronic obstructive pulmonary disease but its activity was never evaluated in clinical trials.
Class (Stereo):
CHEMICAL (RACEMIC)
IPROCROLOL is a beta-adrenoceptor antagonist with antiarrhythmic properties.
Class (Stereo):
CHEMICAL (RACEMIC)
Fursalan was studied as a disinfectant. Information about the current use of this compound is not available.
