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Restrict the search for
m nalidixic acid
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Class (Stereo):
CHEMICAL (ABSOLUTE)
Furbucillin is a synthetic antibacterial agent that has never been marketed. Information about the current use of this drug is not available.
Class (Stereo):
CHEMICAL (RACEMIC)
Furofenac (also known as SAS 650), a drug that has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. It was shown that the furofenac mechanism of action involved the modulation of the platelet cyclooxygenase pathway.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Gemopatrilat is a vasopeptidase inhibitor, that was found to inhibit plasma and renal angiotensin converting enzyme (ACE), as well as renal neutral endopeptidase (NEP). Gemopatrilat is rapidly absorbed, and causes inhibition of circulating and renal ACE and renal NEP after a single oral dose for up to 48 hours in rats. Potentially, this is because the free sulfhydryl group of gemopatrilat forms reversible disulfide linkages with plasma and tissue proteins and is thus eliminated from the body at a very slow rate. Similar metabolism of the compound was found in rat, dog, and human. Gemopatrilat was evaluated for its potential in treatment of antihypertensive activity in hypertension (independent of age, renin and salt status or ethnic origin), as well as its potential as a new therapeutic modality for the treatment of congestive heart failure. The drug was never marketed. A phase II study for treatment of hypertension and heart failure has been discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Pibaxizine is diphenylmethyl piperazine derivatives. It is a histamine H1 receptor antagonist. Animal experiments have shown that it has spasmolytic properties for smooth muscle, particularly in the bronchi, as well as anticholinergic and anti-serotonin activities. It can be concluded that Pibaxizine has a strong protective effect against bronchospasm caused by inhalation of a histamine aerosol. Protection against methacholine-induced bronchospasm was less marked. Pibaxizine had been in phase II clinical trial for the treatment of chronic obstructive pulmonary disease. However, this development was discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Binfloxacin is a topoisomerase inhibitor that was studied as an antibacterial agent.
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Investigational
Source:
INN:tryparsamide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Tryparsamide is an arsenic compound with activity against Spirochaetes bacteria. Tryparsamide is used in the treatment of syphilis and African sleeping sickness. For decades Tryparsamide remained the standard treatment for trypanosomiasis. Tryparsamide has two remarkable properties: first, it increases the resistance of the individual by improving his general physical status; and, second, the high penetrability for nervous tissue which it possesses may increase the potential spirocheticidal action of the drug.
Class (Stereo):
CHEMICAL (RACEMIC)
Terbufibrol, an antihyperlipoproteinemic agent that blocks the hepatic cholesterol synthesis in a step between acetate and HMG-CoA (3-hydroxy-3-methylglutaryl-CoA). Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Terdecamycin, an antibiotic that was studied on the pigs to treat dysentery. Information about the current use of this drug is not available.
Status:
Investigational
Source:
USAN:NIFLURIDIDE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Nifluridide, an experimental insecticide, is used for the control of sucking and biting insects such as Phthiraptera. Nifluridide was systemically active against Triatoma infestans on mice and Rhodnius prolixus on cattle.
