U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2201 - 2210 of 11797 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:


Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.
Potassium magnesium aspartate (K,Mg aspartate) is used in treating and preventing cardiac disruptions caused by electrolytic disturbances, primarily low potassium (K) and magnesium (Mg) levels (e.g. in the treatment with cardiac glycosides and diuretic drugs). It is used as a mineral supplement. The proposed mechanisms of action of magnesium-potassium aspartate include: Stabilization of cellular membranes by normalization of the levels of magnesium and potassium in the cells. Detoxification of ammonia or increase in the tricarboxylic acid-cycle flux. As increased levels of ammonia and depleted levels of potassium and magnesium ions in the plasma are associated with exercise-induced fatigue, this combination of aspartate (which detoxifies ammonia) and magnesium and potassium is particularly relevant in sports nutrition. Potassium magnesium aspartate is reported as an ingredient of Aspara in Japan, Panangin in Russian Federation, Bulgaria, China, Hungary, Romania etc., Asparkam in Georgia. Trophicard in Germany.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Bisdisulizole disodium (also known as disodium phenyl dibenzimidazole tetrasulfonate) under the brand name Neoheliopan AP is marketed in some Europe countries and in Australia. This compound is a part of sunscreens to absorb UVA rays.
Status:
Possibly Marketed Outside US
First approved in 2016

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

1,1,1,3,3-Pentafluoropropane (or pentafluoropropane, or HFC-245fa), a chlorofluorocarbon substitute, is used primarily for spray foam insulation. Pentafluoropropane is metabolized in human with the formation of the minor, but highly toxic metabolite 3,3,3-trifluoropropanoic acid.

Showing 2201 - 2210 of 11797 results