6-Dehydroprogesterone (Pregna-4,6-diene-3,20-dione) is a synthetic derivative and natural metabolite of progesterone and major impurity of dehydrogesterone. 6-Dehydroprogesterone derivatives has been used in hormone replacement therapy for menopausal symptoms and in the treatment of gynecological disorders, but 6-Dehydroprogesterone has never marketed.

Algestone acetophenide, also known as dihydroxyprogesterone acetophenide, is an agonist of the progesterone receptor. Algestone acetophenide in combination with estradiol enanthate is sold under the brand name Deladroxate as a form of long-lasting injectable birth control. The combination provides simultaneously prolonged progestational and estrogenic activities both of which are maintained at effective levels for approximately three weeks after the intramuscular injection of a single dose.