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Details

Stereochemistry ABSOLUTE
Molecular Formula C29H36O4
Molecular Weight 448.5937
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALGESTONE ACETOPHENIDE

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1(O[C@@](C)(O2)C6=CC=CC=C6)C(C)=O

InChI

InChIKey=AHBKIEXBQNRDNL-FVCOMRFXSA-N
InChI=1S/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s1

HIDE SMILES / InChI

Molecular Formula C29H36O4
Molecular Weight 448.5937
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Algestone acetophenide, also known as dihydroxyprogesterone acetophenide, is an agonist of the progesterone receptor. Algestone acetophenide in combination with estradiol enanthate is sold under the brand name Deladroxate as a form of long-lasting injectable birth control. The combination provides simultaneously prolonged progestational and estrogenic activities both of which are maintained at effective levels for approximately three weeks after the intramuscular injection of a single dose.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Deladroxate

PubMed

Sample Use Guides

In Vivo Use Guide
On the eight day (7th-9th) after the onset of menstruation from the last ovulatory cycle, one ml.of Deladroxate (150 mg of dihydroxyprogesterone acetophenide combined with 10 mg of estradiol enanthate) was injected intramuscularly in the deltoid or gluteal region.
Route of Administration: Intramuscular
Substance Class Chemical
Record UNII
OL7KC2O3OT
Record Status Validated (UNII)
Record Version