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Restrict the search for
leucomethylene blue
to a specific field?
Status:
Investigational
Source:
NCT00508664: Phase 2 Interventional Completed Squamous Cell Carcinoma of the Hypopharynx
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Neotetrazolium chloride is used for the histochemical detection of dehydrogenases. Neotetrazolium reduction can be used for discriminating malignant cells from nonmalignant cells. Neotetrazolium chloride is used for the colorimetric estimation of succinic dehydrogenase activity in a tumor sensitivity test to chemotherapeutic agents. Neotetrazolium chloride is also used in the microagglutination test and in the Neotetrazolium Test (NTC) for histologic evaluation of myocardial sections in acute necrobiosis of the myocardium.
Status:
Investigational
Source:
NCT00655421: Phase 3 Interventional Unknown status Oral Cancer
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Toluidine Blue (also known as tolonium chloride or Toluidine blue O) is metachromatic dye used for a variety of histological staining, it selectively stains acidic tissue components (sulfates, carboxylates, and phosphate radicals. Toluidine blue has an affinity for nucleic acids, and therefore binds to nuclear material of tissues with a high DNA and RNA content. It was evaluated the toluidine blue staining in premalignancies, and superficial oral ulceration suggesting malignancy. The study showed 100% sensitivity in the detection of in situ and invasive carcinoma and no false-negative results occurred. The lesions that were diagnosed as dysplasia did not retain stain, and thus gave false-negative results. The reasons could be that the exact mechanisms by which the dye differentially stains malignant or dysplastic tissues remain unknown.
Status:
Investigational
Source:
INN:quinaldine blue [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pinacyanol iodide is a fluorescent cationic cyanine dye used to stain biological specimens. It is the obstetric diagnostic aid. The mechanism of tracing with pinacyanol iodide dyes is based on their lipid solubility. Pinacyanol iodide dyes are more efficacious than classical tracing methodologies especially during early stages of development and consequently have been used to reveal the spatiotemporal patterns of axonal development in different species. The unique properties of the pinacyanol iodide dye tracing method have opened up new avenues for tracing connections in human postmortem specimens. Pinacyanol iodide dye tracing is incompatible with alcohol fixation and paraffin embedding of tissue.
Status:
Investigational
Source:
NCT02322086: Phase 2 Interventional Completed Psoriasis
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Rose Bengal lactone is a polyhalogenated derivative of Fluorescein. Rose Bengal lactone is a dye compound described to produce cell membrane damage. Rose Bengal lactone and other Fluorescein derivatives are also described to modulate the function of ATP-sensitive K+ channels. Rose bengal lactone reacts readily with bases so treatment with triethylamine immediately yields the Rose Bengal salt.
