Details
Stereochemistry | ACHIRAL |
Molecular Formula | C28H20N2O10S2.2Na |
Molecular Weight | 654.575 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].CC1=CC(=C(NC2=CC=C(O)C3=C2C(=O)C4=C(O)C=CC(NC5=C(C=C(C)C=C5)S([O-])(=O)=O)=C4C3=O)C=C1)S([O-])(=O)=O
InChI
InChIKey=LSOBEVFVUSIMGA-UHFFFAOYSA-L
InChI=1S/C28H22N2O10S2.2Na/c1-13-3-5-15(21(11-13)41(35,36)37)29-17-7-9-19(31)25-23(17)27(33)26-20(32)10-8-18(24(26)28(25)34)30-16-6-4-14(2)12-22(16)42(38,39)40;;/h3-12,29-32H,1-2H3,(H,35,36,37)(H,38,39,40);;/q;2*+1/p-2
Molecular Formula | C28H20N2O10S2 |
Molecular Weight | 608.596 |
Charge | -2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Toluidine Blue (also known as tolonium chloride or Toluidine blue O) is metachromatic dye used for a variety of histological staining, it selectively stains acidic tissue components (sulfates, carboxylates, and phosphate radicals. Toluidine blue has an affinity for nucleic acids, and therefore binds to nuclear material of tissues with a high DNA and RNA content. It was evaluated the toluidine blue staining in premalignancies, and superficial oral ulceration suggesting malignancy. The study showed 100% sensitivity in the detection of in situ and invasive carcinoma and no false-negative results occurred. The lesions that were diagnosed as dysplasia did not retain stain, and thus gave false-negative results. The reasons could be that the exact mechanisms by which the dye differentially stains malignant or dysplastic tissues remain unknown.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22923899
Curator's Comment: William Henry Perkin in 1856
Approval Year
PubMed
Title | Date | PubMed |
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Toluidine blue staining for detection of oral premalignant lesions and carcinomas. | 1988 Feb |
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Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas. | 2001 May |
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Toluidine blue: A review of its chemistry and clinical utility. | 2012 May |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11346731
Fifty patients with potentially malignant epithelial lesions (PMELs) and superficial oral ulcerations suggestive of malignancy were selected. All lesions were submitted to staining with an aqueous solution of 1% toluidine blue, followed by biopsy and histologic analysis. Histologic diagnosis revealed that 14% of the lesions analyzed were in situ carcinoma and invasive squamous cell carcinomas, 12% were epithelial dysplasias, 13% were keratosis, 40% were lichen planus, and 8% were other benign lesions. The sensitivity of the staining was 77%, the specificity 67%, and the positive and negative predictive values 43.5% and 88.9%, respectively. Staining with toluidine blue was demonstrated to be highly reliable in the detection of in situ carcinoma and invasive squamous cell carcinoma, because false-negative results for the lesions did not occur. Toluidine blue staining is an adjunct to clinical judgment and not a substitute for either judgment or biopsy.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:09:52 GMT 2023
by
admin
on
Fri Dec 15 18:09:52 GMT 2023
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Record UNII |
JZ7CEV4HPK
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Record Status |
Validated (UNII)
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Record Version |
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76675
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DTXSID00185886
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221-718-2
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37251-80-2
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3209-30-1
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