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Search results for "ATC|ALIMENTARY TRACT AND METABOLISM|LAXATIVES" in comments (approximate match)
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(12)(iv)(B) laxative:stimulant laxative danthron
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Danthron, a natural product, was originally extracted from the roots and rhizome of Polygonaceae plant. Danthron is an anthraquinone. Danthron has been widely administrated as a laxative since the 1900s. In the United States, danthron has been forbidden to continual use as laxative because it is considered to be a carcinogen. In the UK, it is not marketed alone but in combination with poloxamer 188 as co-danthramer and with docusate as co-danthrusate; in the UK, its use is strictly restricted to the elderly and to the terminally ill of all ages because of concerns about carcinogenicity and hepatotoxicity. It has only a limited role in the treatment of constipation.
Status:
Possibly Marketed Outside US
First approved in 2005
Source:
ANDA077109
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pentaerythritol is an inactive metabolite of pentaerythritol tetranitrate, a drug that is used for the treatment of angina pectoris.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Bisoxatin (Laxonalin, Wylaxine) acetate is a stimulant laxative that has been used in the treatment of constipation. The drug showed good effects to habitual constipation and dolichocolon but was not sufficient acting in megacolon. It seems that the drug is effective to constipation due to functional disorders but the effect is not sufficient to constipation caused chiefly by organic colonic changes. No side effect was observed even in long term administration.
Status:
Possibly Marketed Outside US
Source:
NCT04436601: Phase 4 Interventional Recruiting Hepatic Encephalopathy
(2020)
Source URL:
First approved in 1960
Source:
Cetacaine Topical Anesthetic by Cetylite Industries, Inc.
Source URL:
Class:
MIXTURE
Status:
US Approved OTC
Source:
21 CFR 346.14(a)(7) anorectal:protectant mineral oil
Source URL:
First marketed in 1921
Source:
Liquid Petrolatum U.S.P.
Source URL:
Class:
STRUCTURALLY DIVERSE
Status:
US Approved Allergenic Extract
(1967)
Source:
BLA101376
(1967)
Source URL:
First marketed in 1921
Class:
STRUCTURALLY DIVERSE
Status:
US Previously Marketed
Source:
Castor Oil U.S.P.
(1921)
Source URL:
First marketed in 1921
Class:
STRUCTURALLY DIVERSE
Status:
Possibly Marketed Outside US
First approved in 1987
Source:
M012
Source URL:
Class:
G1 SPECIFIED SUBSTANCE
Status:
US Approved Rx
(2022)
Source:
ANDA212789
(2022)
Source URL:
First approved in 2012
Source:
PREPOPIK by FERRING PHARMS INC
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Picosulfuric acid (as sodium picosulfate) is a contact laxative, which is used in combination with: magnesium oxide, and anhydrous citric acid for cleansing of the colon as a preparation for colonoscopy in adults. Sodium picosulfate is a prodrug. It has no significant direct physiological effect on the intestine. But it is hydrolyzed by colonic bacteria to form an active metabolite: bis-(p-hydroxy-phenyl)-pyridyl-2-methane, BHPM, which acts directly on the colonic mucosa to stimulate colonic peristalsis
Status:
US Approved Rx
(2016)
Source:
NDA208271
(2016)
Source URL:
First approved in 2008
Source:
NDA021964
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Methylnaltrexone, is a peripherally acting μ-opioid receptor antagonist that acts on the gastrointestinal tract to inhibit the opioid-induced decrease in gastric motility and transit time. It is used to treat opiate-induced constipation in adults with chronic non-cancer pain and in adults with advanced illness who are receiving palliative care.
