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Details

Stereochemistry ACHIRAL
Molecular Formula C14H8O4
Molecular Weight 240.2109
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DANTHRON

SMILES

OC1=CC=CC2=C1C(=O)C3=C(O)C=CC=C3C2=O

InChI

InChIKey=QBPFLULOKWLNNW-UHFFFAOYSA-N
InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H

HIDE SMILES / InChI

Molecular Formula C14H8O4
Molecular Weight 240.2109
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Danthron, a natural product, was originally extracted from the roots and rhizome of Polygonaceae plant. Danthron is an anthraquinone. Danthron has been widely administrated as a laxative since the 1900s. In the United States, danthron has been forbidden to continual use as laxative because it is considered to be a carcinogen. In the UK, it is not marketed alone but in combination with poloxamer 188 as co-danthramer and with docusate as co-danthrusate; in the UK, its use is strictly restricted to the elderly and to the terminally ill of all ages because of concerns about carcinogenicity and hepatotoxicity. It has only a limited role in the treatment of constipation.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
14.0 µM [IC50]
7.5 µM [Kd]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Normax

Doses

AEs

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer






Drug as perpetrator​

Drug as victim

PubMed

Sample Use Guides

In Vivo Use Guide
The usual dose for adults is one to three capsules at bedtime. The usual dose for children aged 6-12 years is one capsule at bedtime. Normax 50mg/60mg Capsules are not recommended for use by children under 6 years of age. This product should be taken orally (by mouth). You must swallow the capsules whole with a drink of water. The capsules must not be crushed or chewed. Normax 50mg/60mg Capsules normally begin to work 8 hours after the dose is taken.
Route of Administration: Oral
In Vitro Use Guide
10 uM danthron reduces growth of B16-F10 melanoma by 83%
Substance Class Chemical
Record UNII
Z4XE6IBF3V
Record Status Validated (UNII)
Record Version