BISOXATIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H15NO4
Molecular Weight	333.3374
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C=C1)C2(OC3=CC=CC=C3NC2=O)C4=CC=C(O)C=C4

InChI

InChIKey=BPKUDUSVDVLOPY-UHFFFAOYSA-N

InChI=1S/C20H15NO4/c22-15-9-5-13(6-10-15)20(14-7-11-16(23)12-8-14)19(24)21-17-3-1-2-4-18(17)25-20/h1-12,22-23H,(H,21,24)

HIDE SMILES / InChI

Molecular Formula	C20H15NO4
Molecular Weight	333.3374
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/205764/1/ngh033006_1122.pdf
Curator's Comment: description was created based on several sources, including http://bijsluiters.fagg-afmps.be/registrationSearchServlet?key=BE022924&leafletType=leafletFR

Bisoxatin (Laxonalin, Wylaxine) acetate is a stimulant laxative that has been used in the treatment of constipation. The drug showed good effects to habitual constipation and dolichocolon but was not sufficient acting in megacolon. It seems that the drug is effective to constipation due to functional disorders but the effect is not sufficient to constipation caused chiefly by organic colonic changes. No side effect was observed even in long term administration.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Constipation 112 Sources: http://www.ncbi.nlm.nih.gov/pubmed/4996225/	Primary		Approved 8429	Wylaxine Approved Use Wylaxine is recommended for the treatment of constipation symptoms (non-mechanical origin only) and for preparing a gastrointestinal examination.

PubMed

Title	Date	PubMed
Bisoxatin acetate as a postpartum oral laxative: a random double blind controlled experiment in 106 subjects.	1968 Jan	4865759
A compilation of LD50 values in newborn and adult animals.	1971 Jan	5542824
Treatment of acute and chronic constipation with bisoxatin acetate and bisacodyl. Double-blind crossover study.	1971 Jun	4996225
[Treatment of chronic constipation with a contact laxative in pearl form: bisoxatin acetate].	1972	4681351
[Colon cleansing by Wylaxine as a preparation for barium enema fluoroscopy (author's transl)].	1974 Jul-Aug	4422901

Patents

Sample Use Guides

In Vivo Use Guide

120 mg in the evening at bedtime

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:52:11 GMT 2023` Edited by `admin` on `Sat Dec 16 15:52:11 GMT 2023`
Record UNII	7C75N0L7FP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BISOXATIN

Official Name

English

bisoxatin [INN]

Common Name

English

Bisoxatin [WHO-DD]

Common Name

English

2,2-BIS(P-HYDROXYPHENYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA06AB09