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Restrict the search for
allopurinol
to a specific field?
Status:
Other
Class:
MIXTURE
Status:
Investigational
Source:
NCT03830736: Not Applicable Interventional Completed Postprandial Glucose Regulation
(2019)
Source URL:
Class:
PROTEIN
Status:
Possibly Marketed Outside US
Source:
NCT03226899: Phase 4 Interventional Terminated Gout
(2017)
Source URL:
Class:
PROTEIN
Status:
US Approved Rx
(2007)
Source:
ANDA078253
(2007)
Source URL:
First approved in 1966
Source:
NDA016084
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Allopurinol is a xanthine oxidase inhibitor used to decrease high blood uric acid levels. Allopurinol is specifically used to prevent gout, prevent specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy. Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Allopurinol is a structural analog of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid, the end product of purine metabolism in man. Allopurinol is metabolized to the corresponding xanthine analog, oxypurinol (Allopurinol), which also is an inhibitor of xanthine oxidase. Allopurinol is taken by mouth or injected into a vein. Common side effects, when used by mouth, include itchiness and rash. Common side effects when used by injection include vomiting and kidney problems.
![Structure of ALTERNATIVE DEFINITION for [ALLOPURINOL]](/img/7a47b7c0-e54c-806e-bd15-e69c691ee510.svg?size=200&context=hxbfgfgcfz)
