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Restrict the search for
angiotensin ii
to a specific field?
Status:
Possibly Marketed Outside US
Source:
NCT00726713: Phase 4 Interventional Completed Type 2 Diabetic Peripheral Neuropathy (DPN)
(2008)
Source URL:
First approved in 2011
Source:
EnLyte by Jaymac Pharma
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2011)
Source URL:
First approved in 2011
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP) by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. Around 1960 Earl W. Sutherland, Jr. showed that cyclic adenosine monophosphate (cAMP) serves as the secondary messenger within the cell. Cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally inactive as a tetrameric holoenzyme, consisting of two catalytic and two regulatory units with the regulatory units blocking the catalytic centers of the catalytic units. Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus enabling those catalytic units to phosphorylate substrate proteins. It was discovered, that melanocytes require the RAS/RAF/MEK/ERK and the cyclic AMP (cAMP) signaling pathways to maintain the fine balance between proliferation and differentiation. cAMP suppressed CRAF activity in melanocytes and that was essential to suppress the oncogenic potential of CRAF in the cells. When RAS was mutated in melanoma, the cells switched their signaling from BRAF to CRAF. That switch was accompanied by dysregulated cAMP signaling, a step that was necessary to allow CRAF to signal to MEK. Thus, a fundamental switch in RAF isoform usage occurs when RAS was mutated in melanoma, and that occurs in the context of disrupted cAMP signaling. These data have important implications for the development of therapeutic strategies to treat this life-threatening disease.
Status:
Possibly Marketed Outside US
Source:
Sooryehan Pure-Whitening Essence by Lg Household & Health Care Ltd.
Source URL:
First approved in 2010
Source:
Sooryehan Pure-Whitening by LG Household and Healthcare, Inc.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Polydatin (PD, also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,40 ,5-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), a traditional Chinese medicine that has long been used in China as an analgesic, anti-pyretic, diuretic and expectorant. It is a glucoside of resveratrol (3,40 ,5-trihydroxystilbene) in which the glucoside group bound to the position C-3 substitutes a hydroxyl group, belonging to stilbene phytoalexins. Polydatin can also be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.
Status:
Possibly Marketed Outside US
Source:
HERBALIFE SKIN 7 DAY RESULTS KIT
Source URL:
First approved in 2010
Source:
21 CFR 333B
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Hexylene glycol is a small molecular weight surfactant. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. It is used to thin out heavy compositions and create a thinner, more spreadable product. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene glycol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Hexylene glycol is widely used in the coating industry as a component for lacquers, varnishes, printing inks and both oil and water-based paints. Although the FDA has approved Hexylene Glycol and the CIR found it an acceptable solvent in skin care products, some studies have shown that it is an irritant.
Status:
Possibly Marketed Outside US
Source:
505G(a)(3)
(2013)
Source URL:
First approved in 2010
Source:
M021
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
Cover Fx Mattifying Prime And Set
Source URL:
First approved in 2010
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ethyl oleate is a fatty acid ester used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids. In vivo studies have demonstrated that Ethyl oleate and other fatty acid esters are also rapidly hydrolyzed to ethanol and free fatty acid. Ethyl oleate is one of the fatty acid ethyl esters (FAEE) that is formed in the body after ingestion of ethanol. There is a growing body of research literature that implicates FAEEs such as ethyl oleate as the toxic mediators of ethanol in the body (pancreas, liver, heart, and brain). Among the speculations is that ethyl oleate may be the toxic mediator of alcohol in fetal alcohol syndrome. The oral ingestion of ethyl oleate has been carefully studied and due to rapid degradation in the digestive tract, it appears safe for oral ingestion. Ethyl oleate is not currently approved by the U.S. Food and Drug Administration for any injectable use. However, it is used by compounding pharmacies as a vehicle for intramuscular drug delivery, in some cases to prepare the daily doses of progesterone in support of pregnancy. Studies which document the safe use of ethyl oleate in pregnancy for both the mother and the fetus have never been performed.
Status:
Possibly Marketed Outside US
First approved in 2010
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Ethylene is a gaseous organic compound. Ethylene is an important raw material for the chemical industry and feedstock for 30 percent of all petrochemicals. Ethylene is used for the production of many plastics, including polyethylene (PE), polyvinyl chloride (PVC), PET, cellulose acetate and polyvinyl acetate polymer. Ethylene is used in the production of specialty glass for the automotive industry (car glass). Ethylene is used as oxy-fuel gas in metal cutting, welding and high velocity thermal spraying. Ethylene is used as refrigerant, especially in LNG liquefaction plants. Ethylene is used in the extraction of rubber. Ethylene was used as a general anesthetic in major as well as minor surgery: tonsillectomies, appendectomies, Caesarian sections, hysterectomies, gastro-enterostomies, cholecystectomies, and other operations where the age of the patient ranges
from three days to eighty-four or five years. Ethylene is the first-identified plant hormone known to regulate numerous processes in plant growth, development, and response to biotic and abiotic stresses. Ethylene is best known for its effect on fruit ripening and organ abscission, and thus has great commercial importance in agriculture.
Status:
Possibly Marketed Outside US
Source:
21 CFR 347
(2010)
Source URL:
First approved in 2010
Source:
21 CFR 347
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
The cationic surfactant, stearamidoethyl diethylamine (SD) is an emulsifier used in topical medications and cosmetics. Stearamidoethyl Diethylamine is an ingredient found in a variety of cosmetics and personal care products, primarily in shampoos and other hair care formulas, as an emulsifier, anti-static agent, and hair conditioner. It has been reported to cause allergic contact dermatitis.
Status:
Possibly Marketed Outside US
First approved in 2010
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Ethyl linoleate (ELA) is an essential fatty acid used in many cosmetics for its anti-inflammatory properties. It inhibits the action of the reactive species of oxygen released by neutrophils due to an excess of bacteria, and prevents the hyperkeratinization induced by a lack of linoleic acid. Though there are few reports stating the antiinflammatory activity of ELA, the mechanism by which ELA exhibits anti-inflammatory activity remains unclear. An aqueous emulsion of ethyl linoleate can be used as parenteral injection for curring ailments where a high plasma-cholesterol level of the blood is indicated. Improvements in liver function tests during the administration of ELA were noticed in almost all cases with a few aggravated exceptions. The administration of ELA can expect the satisfactory response to the patients both with liver cirrhosis and with chronic hepatitis.
Status:
Possibly Marketed Outside US
Source:
NCT04677712: Phase 4 Interventional Completed Edematous Fibrosclerotic Panniculopathy (EFP)
(2020)
Source URL:
First approved in 2010
Source:
Skin Doctors Photo Age Reverse by Cat Media Pty Ltd
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Butylene glycol, or 1, 3-Butanediol, is an organic compoud found in peppers (Capsicum annuum). It is used as a solvent for flavoring agents, as a viscosity-descreasing agent in cosmetics and skin care products and as a hypoglycaemic agent for diabetics.
