HEXYLENE GLYCOL

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H14O2
Molecular Weight	118.1742
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CC(C)(C)O

InChI

InChIKey=SVTBMSDMJJWYQN-UHFFFAOYSA-N

InChI=1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C6H14O2
Molecular Weight	118.1742
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://thedermreview.com/hexylene-glycol/ | https://www.arkema.com/export/shared/.content/media/downloads/socialresponsability/safety-summuries/Thiochemicals-hexylene-glycol-2012-04-30.pdf | https://www.truthinaging.com/ingredients/hexylene-glycol

Hexylene glycol is a small molecular weight surfactant. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. It is used to thin out heavy compositions and create a thinner, more spreadable product. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene glycol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Hexylene glycol is widely used in the coating industry as a component for lacquers, varnishes, printing inks and both oil and water-based paints. Although the FDA has approved Hexylene Glycol and the CIR found it an acceptable solvent in skin care products, some studies have shown that it is an irritant.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34f3a8d7-8e9a-472b-a76a-107042049dec	Inactive ingredient		Approved 8583	HERBALIFE SKIN 7 DAY RESULTS KIT Approved Use Helps prevent sunburn. If used as directed with other sun protection measures, decreases the risk of skin cancer and early skin aging caused by the sun.

PubMed

Title	Date	PubMed
Crystallization and preliminary X-ray analysis of a marine diatom-infecting single-stranded RNA virus.	2010-11-01	21045292
Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI.	2010-10-29	20739283
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.	2010-10-20	20812704
Regulation of response regulator autophosphorylation through interdomain contacts.	2010-10-15	20702407
Structural insights into serine-rich fimbriae from Gram-positive bacteria.	2010-10-15	20584910
Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.	2010-10-01	20944225
Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding.	2010-10-01	20944218
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution.	2010-10-01	20944216
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.	2010-09-08	20826347
A new crystal form of Lys48-linked diubiquitin.	2010-09-01	20823512
Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.	2010-08-06	20691033
Crystallisation of wild-type and variant forms of a recombinant plant enzyme β-D-glucan glucohydrolase from barley (Hordeum vulgare L.) and preliminary X-ray analysis.	2010-07-19	20717535
X-ray analysis of bilirubin oxidase from Myrothecium verrucaria at 2.3 A resolution using a twinned crystal.	2010-07-01	20606269
Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp.	2010-06	20516625
Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.	2010-06	20353826
X-ray structures of Bacillus pallidus d-arabinose isomerase and its complex with l-fucitol.	2010-06	20123133
Progress in rational methods of cryoprotection in macromolecular crystallography.	2010-04	20382989
The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.	2010-02-18	20174634
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.	2010-02-12	19913036
Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii.	2010-02-10	20161776
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.	2009-12-10	19788411
Purification, crystallization and preliminary X-ray analysis of a deletion mutant of a major buckwheat allergen.	2009-12-01	20054125
Interpreting a low resolution map of human U1 snRNP using anomalous scatterers.	2009-07-15	19604473
Substrate binding in the FAD-dependent hydroxynitrile lyase from almond provides insight into the mechanism of cyanohydrin formation and explains the absence of dehydrogenation activity.	2009-04-21	19256550
Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution.	2009-04	19307719
Crystallization and preliminary X-ray diffraction analysis of a complex between the electron-transfer partners hexameric Cu-containing nitrite reductase and pseudoazurin.	2009-02-01	19193999
Substrate binding induces structural changes in cytochrome P450cam.	2009-02-01	19193991
Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multienzyme complex.	2008-12-10	19081062
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.	2008-09-30	18771296
Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation.	2008-07-29	18597481
Duplex structure of a minimal nucleic acid.	2008-07-02	18529005
Protecting role of cosolvents in protein denaturation by SDS: a structural study.	2008-06-03	18522744
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.	2008-06	18422643
Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer.	2008-04	17957772
Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.	2008-02-27	18302803
Refolding SDS-denatured proteins by the addition of amphipathic cosolvents.	2008-02-01	18083190
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.	2008	18978942
DNA conformational effects on the interaction of netropsin with A-tract sequences.	2007-12-25	18044972
Crystallization, data collection and processing of the chymotrypsin-BTCI-trypsin ternary complex.	2007-12-01	18084102
Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents.	2007-11-15	17655855
Crystallization and preliminary X-ray crystallographic study of [NiFe]-hydrogenase maturation factor HypE from Thermococcus kodakaraensis KOD1.	2007-09-01	17768349
The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode.	2007-09	17766384
Overexpression, purification, crystallization and preliminary structural studies of catabolic ornithine transcarbamylase from Lactobacillus hilgardii.	2007-07-01	17620711
Structure of the ThDP-dependent enzyme benzaldehyde lyase refined to 1.65 A resolution.	2007-07-01	17620706
Preliminary crystallographic analysis of L-2-keto-3-deoxyarabonate dehydratase, an enzyme involved in an alternative bacterial pathway of L-arabinose metabolism.	2007-05-01	17565178
In silico prediction of SARS protease inhibitors by virtual high throughput screening.	2007-04	17461975
Purification, crystallization and preliminary crystallographic analysis of the putative thiamine-biosynthesis protein PH1313 from Pyrococcus horikoshii OT3.	2007-01-01	17183176
Crystallization and preliminary X-ray diffraction studies of a hyperthermophilic Rieske protein variant (SDX-triple) with an engineered rubredoxin-like mononuclear iron site.	2006-10-01	17012793
Structure of Bacillus halmapalus alpha-amylase crystallized with and without the substrate analogue acarbose and maltose.	2006-09-01	16946462
Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.	2006-09-01	16946458

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:23:43 GMT 2025` Edited by `admin` on `Mon Mar 31 18:23:43 GMT 2025`
Record UNII	KEH0A3F75J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXYLENE GLYCOL

Official Name

English

NSC-8098

Preferred Name

English

HEXYLENE GLYCOL [USP-RS]

Common Name

English

HEXYLENE GLYCOL [MI]

Common Name

English

2-Methyl-2,4-pentanediol

Systematic Name

English

HEXYLENE GLYCOL [HSDB]

Common Name

English

HEXYLENE GLYCOL [MART.]

Common Name

English

2,4-PENTANEDIOL, 2-METHYL-

Systematic Name

English

HEXYLENE GLYCOL [II]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

68601