HEXYLENE GLYCOL

First approved in 2009

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H14O2
Molecular Weight	118.1742
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CC(C)(C)O

InChI

InChIKey=SVTBMSDMJJWYQN-UHFFFAOYSA-N

InChI=1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C6H14O2
Molecular Weight	118.1742
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://thedermreview.com/hexylene-glycol/ | https://www.arkema.com/export/shared/.content/media/downloads/socialresponsability/safety-summuries/Thiochemicals-hexylene-glycol-2012-04-30.pdf | https://www.truthinaging.com/ingredients/hexylene-glycol

Hexylene glycol is a small molecular weight surfactant. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. It is used to thin out heavy compositions and create a thinner, more spreadable product. Hexylene Glycol is a solvent and viscosity agent used in many skin care products. Hexylene glycol is used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Hexylene glycol is widely used in the coating industry as a component for lacquers, varnishes, printing inks and both oil and water-based paints. Although the FDA has approved Hexylene Glycol and the CIR found it an acceptable solvent in skin care products, some studies have shown that it is an irritant.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34f3a8d7-8e9a-472b-a76a-107042049dec	Inactive ingredient		Approved 8429	HERBALIFE SKIN 7 DAY RESULTS KIT Approved Use Helps prevent sunburn. If used as directed with other sun protection measures, decreases the risk of skin cancer and early skin aging caused by the sun.

PubMed

Title	Date	PubMed
An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase.	2001 Mar 23	11254389
Structure of the neurotoxic complex vipoxin at 1.4 A resolution.	2001 Nov	11679719
Screening of nucleation conditions using levitated drops for protein crystallization.	2003 Apr 1	12705610
Novel titanium compounds for metal-organic chemical vapor deposition of titanium dioxide films with an ultrahigh deposition rate.	2003 Apr 7	12665373
The crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13.	2003 May 23	12621044
The crystal structure of glutamyl endopeptidase from Bacillus intermedius reveals a structural link between zymogen activation and charge compensation.	2004 Mar 16	15005613
A redetermination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6 A resolution using sulfur-SAS at 1.54 A wavelength.	2004 Sep	15333929
Crystallization and preliminary X-ray analysis of binary and ternary complexes of Haloferax mediterranei glucose dehydrogenase.	2005 Aug 1	16511145
Pentane-1,5-diol as a percutaneous absorption enhancer.	2005 Dec	16215760
Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu.	2005 Jan 1	16508104
Effect of organic cosolvents on the free solution mobility of curved and normal DNA molecules.	2006 Apr	16609931
Crystallization and preliminary X-ray analysis of the rhamnogalacturonan lyase YesW from Bacillus subtilis strain 168, a member of polysaccharide lyase family 11.	2006 May 1	16682770
Structure of Bacillus halmapalus alpha-amylase crystallized with and without the substrate analogue acarbose and maltose.	2006 Sep 1	16946462
Structure of the ThDP-dependent enzyme benzaldehyde lyase refined to 1.65 A resolution.	2007 Jul 1	17620706
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.	2008	18978942
Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer.	2008 Apr	17957772
Refolding SDS-denatured proteins by the addition of amphipathic cosolvents.	2008 Feb 1	18083190
Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.	2008 Feb 27	18302803
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.	2008 Jun	18422643
Protecting role of cosolvents in protein denaturation by SDS: a structural study.	2008 Jun 3	18522744
Purification, crystallization and preliminary X-ray analysis of a deletion mutant of a major buckwheat allergen.	2009 Dec 1	20054125
Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii.	2010 Feb 10	20161776
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.	2010 Feb 12	19913036
Crystallisation of wild-type and variant forms of a recombinant plant enzyme β-D-glucan glucohydrolase from barley (Hordeum vulgare L.) and preliminary X-ray analysis.	2010 Jul 19	20717535
Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.	2010 Jun	20353826
X-ray structures of Bacillus pallidus d-arabinose isomerase and its complex with l-fucitol.	2010 Jun	20123133
Crystallization and preliminary X-ray analysis of a marine diatom-infecting single-stranded RNA virus.	2010 Nov 1	21045292
Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.	2010 Oct 1	20944225
Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding.	2010 Oct 1	20944218
Regulation of response regulator autophosphorylation through interdomain contacts.	2010 Oct 15	20702407
A new crystal form of Lys48-linked diubiquitin.	2010 Sep 1	20823512
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.	2010 Sep 8	20826347

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:30 GMT 2023` Edited by `admin` on `Fri Dec 15 16:16:30 GMT 2023`
Record UNII	KEH0A3F75J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXYLENE GLYCOL

Official Name

English

HEXYLENE GLYCOL [USP-RS]

Common Name

English

HEXYLENE GLYCOL [MI]

Common Name

English

2-Methyl-2,4-pentanediol

Systematic Name

English

HEXYLENE GLYCOL [HSDB]

Common Name

English

HEXYLENE GLYCOL [MART.]

Common Name

English

NSC-8098

Code

English

2,4-PENTANEDIOL, 2-METHYL-

Systematic Name

English

HEXYLENE GLYCOL [II]

Common Name

English

HEXYLENE GLYCOL [INCI]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

68601