BUTYLENE GLYCOL

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C4H10O2
Molecular Weight	90.121
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CCO

InChI

InChIKey=PUPZLCDOIYMWBV-UHFFFAOYSA-N

InChI=1S/C4H10O2/c1-4(6)2-3-5/h4-6H,2-3H2,1H3

HIDE SMILES / InChI

Molecular Formula	C4H10O2
Molecular Weight	90.121
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-butanediol | https://www.upichem.com/products/13-butylene-glycol-cosmetic-grade

Butylene glycol, or 1, 3-Butanediol, is an organic compoud found in peppers (Capsicum annuum). It is used as a solvent for flavoring agents, as a viscosity-descreasing agent in cosmetics and skin care products and as a hypoglycaemic agent for diabetics.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 83 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f6db0332-58ed-4c82-a9dc-7fac621f1ac1	Inactive ingredient		Approved 8307	REVERSE IT KIT Approved Use PROTECTS AGAINST SUNBURN Launch Date 1.40400001E12

PubMed

Title	Date	PubMed
Purification and characterization of L-2,3-butanediol dehydrogenase of Brevibacterium saccharolyticum C-1012 expressed in Escherichia coli.	2001 Aug	11577733
Subtilisin-catalyzed synthesis of amino acid and peptide esters. Application in a two-step enzymatic ligation strategy.	2001 Dec 27	11784166
Adverse events, including death, associated with the use of 1,4-butanediol.	2001 Jan 11	11150358
Biodegradation of aliphatic-aromatic copolyesters: evaluation of the final biodegradability and ecotoxicological impact of degradation intermediates.	2001 Jul	11444312
Hydrolytic degradation of poly(carbonate)-urethanes by monocyte-derived macrophages.	2001 Nov	11575477
Redirection of pyruvate catabolism in Lactococcus lactis by selection of mutants with additional growth requirements.	2001 Sep	11601628
[GHB--dangerous, addictive and uncontrollable "party drug"].	2001 Sep 19	11602959
Utilization of quinolone drugs as monomers: characterization of the synthesis reaction products for poly(norfloxacin diisocyanatododecane polycaprolactone).	2001 Spring	11749164
Phase separation and physical properties of PEO-containing poly(ether ester amide)s.	2002	12555900
The effect of oxidation on the enzyme-catalyzed hydrolytic biodegradation of poly(urethane)s.	2002	12182550
Treatment of a 1,4-butanediol poisoning with fomepizole.	2002	11990207
Capillary gas chromatographic determination of 1,4-butanediol and gamma-hydroxybutyrate in human plasma and urine.	2002 Apr 5	11996487
Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography.	2002 Feb 18	11909651
A novel route for synthesis of gamma-butyrolactone through the coupling of hydrogenation and dehydrogenation.	2002 Feb 7	12120391
Surface characterization and platelet adhesion studies of aliphatic polyurethanes grafted by fluorocarbon oligomers: effect of fluorocarbon chain length and carboxylic acid group.	2002 Jan	15348203
WBC filtration of whole blood after prolonged storage at ambient temperature by use of an in-line filter collection system.	2002 Jun	12147026
Anabolic androgenic steroid affects competitive behaviour, behavioural response to ethanol and brain serotonin levels.	2002 Jun 15	12048171
A simple GC method for determination of cryoprotector diols 1,4-butanediol or 2,3-butanediol in isolated rat hepatocytes.	2002 Mar-Apr	12050779
Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities.	2002 Oct	12162329
Production of a polyester degrading extracellular hydrolase from Thermomonospora fusca.	2002 Sep-Oct	12363342
Purification and characterization of novel salt-active acharan sulfate lyase from Bacteroides stercoris HJ-15.	2003 Aug	12869191
Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.	2003 Jul 15	12697025
Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media.	2003 Mar	12882564
Chiral direction and interconnection of helical three-connected networks in metal-organic frameworks.	2003 Mar 10	12611524
Lipase-catalyzed polycondensations: effect of substrates and solvent on chain formation, dispersity, and end-group structure.	2003 May-Jun	12741768
Cellular interactions and degradation of aliphatic poly(ester amide)s derived from glycine and/or 4-amino butyric acid.	2003 Sep	12809774
Production of L-2,3-butanediol by a new pathway constructed in Escherichia coli.	2004	15548307
The gamma-hydroxybutyrate withdrawal syndrome.	2004	15298492
Comparison of the actions of gamma-butyrolactone and 1,4-butanediol in Swiss-Webster mice.	2004 Apr	15099915
Changes in macrophage function and morphology due to biomedical polyurethane surfaces undergoing biodegradation.	2004 Apr	14978730
Butane-1,4-diyl bis(chloroacetate).	2004 Dec	15579962
Preparation of macrocyclic 15N-labelled oligoaminodeoxysaccharides as probes for RNA-binding.	2004 Dec 7	15565236
Determination of gamma-hydroxybutyric acid in biological fluids by using capillary electrophoresis with indirect detection.	2004 Feb 5	14698260
Development of a solid-phase extraction method for simultaneous extraction of adipic acid, succinic acid and 1,4-butanediol formed during hydrolysis of poly(butylene adipate) and poly(butylene succinate).	2004 Jan 2	14753784
Comparison of monolithic silica and polymethacrylate capillary columns for LC.	2004 Jul	15354556
Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.	2004 Jul	14991222
Monolithic columns with mixed modes of reversed-phase and anion-exchange stationary phase for capillary electrochromatography.	2004 Jul 30	15354443
4-methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid.	2004 Oct	15542758
Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene.	2004 Oct	15309606
GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier.	2004 Oct	15173314
Optimization of binary porogen solvent composition for preparation of butyl methacrylate monoliths in capillary liquid chromatography.	2004 Sep 17	15499916
Biodegradation of aliphatic homopolyesters and aliphatic-aromatic copolyesters by anaerobic microorganisms.	2004 Sep-Oct	15360276
Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs.	2005 Feb 2	15653166

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 16 15:48:32 UTC 2022` Edited by `admin` on `Fri Dec 16 15:48:32 UTC 2022`
Record UNII	3XUS85K0RA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTYLENE GLYCOL

Official Name

English

1,3-BUTANEDIOL

Systematic Name

English

1,3-BUTYLENE GLYCOL [MI]

Common Name

English

NSC-402145

Code

English

1,3 BUTYLENE GLYCOL [FHFI]

Common Name

English

BUTYLENE GLYCOL [INCI]

Common Name

English

1,3-BUTYLENE GLYCOL [FCC]

Common Name

English

1,3-BUTANDIOL

Systematic Name

English

1,3-DIHYDROXYBUTANE

Systematic Name

English

1,3-Butylene glycol

Systematic Name

English

1,3 BUTYLENE GLYCOL, (±)-

Common Name

English

BUTANE-1,3-DIOL

Systematic Name

English

1,3-BUTANEDIOL [HSDB]

Common Name

English

BUTYLENE GLYCOL [II]

Common Name

English

(RS)-1,3-BUTANDIOL

Systematic Name

English

1-METHYL-1,3-PROPANEDIOL

Systematic Name

English

BUTANE-1,3-DIOL [USP-RS]

Common Name

English

1,3-butandiol [WHO-DD]

Common Name

English

1,3 BUTYLENE GLYCOL

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

42205