BUTYLENE GLYCOL

Possibly Marketed Outside US

First approved in 2010

Details

Stereochemistry	RACEMIC
Molecular Formula	C4H10O2
Molecular Weight	90.121
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)CCO

InChI

InChIKey=PUPZLCDOIYMWBV-UHFFFAOYSA-N

InChI=1S/C4H10O2/c1-4(6)2-3-5/h4-6H,2-3H2,1H3

HIDE SMILES / InChI

Molecular Formula	C4H10O2
Molecular Weight	90.121
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-butanediol | https://www.upichem.com/products/13-butylene-glycol-cosmetic-grade

Butylene glycol, or 1, 3-Butanediol, is an organic compoud found in peppers (Capsicum annuum). It is used as a solvent for flavoring agents, as a viscosity-descreasing agent in cosmetics and skin care products and as a hypoglycaemic agent for diabetics.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f6db0332-58ed-4c82-a9dc-7fac621f1ac1	Inactive ingredient		Approved 8583	REVERSE IT KIT Approved Use PROTECTS AGAINST SUNBURN Launch Date 2014

PubMed

Title	Date	PubMed
Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs.	2005-02-02	15653166
In vitro degradation of polyurethane orthodontic elastomeric modules.	2005-01	15634305
Preparation of macrocyclic 15N-labelled oligoaminodeoxysaccharides as probes for RNA-binding.	2004-12-07	15565236
Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system.	2004-12-03	15588627
The inkjet cleaner "Hurricane"--another GhB recipe.	2004-12	15587253
Butane-1,4-diyl bis(chloroacetate).	2004-12	15579962
Simultaneous analysis of gamma-hydroxybutyric acid and its precursors in urine using liquid chromatography-tandem mass spectrometry.	2004-11-12	15595536
4-methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid.	2004-10	15542758
Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene.	2004-10	15309606
GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier.	2004-10	15173314
Optimization of binary porogen solvent composition for preparation of butyl methacrylate monoliths in capillary liquid chromatography.	2004-09-17	15499916
Biodegradation of aliphatic homopolyesters and aliphatic-aromatic copolyesters by anaerobic microorganisms.	2004-09-14	15360276
Adsorption of naphthalene on zeolite from aqueous solution.	2004-09-01	15276034
Monolithic columns with mixed modes of reversed-phase and anion-exchange stationary phase for capillary electrochromatography.	2004-07-30	15354443
Comparison of monolithic silica and polymethacrylate capillary columns for LC.	2004-07	15354556
Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats.	2004-07	14991222
The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors.	2004-05	14742739
Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration.	2004-04	15332611
Comparison of the actions of gamma-butyrolactone and 1,4-butanediol in Swiss-Webster mice.	2004-04	15099915
Changes in macrophage function and morphology due to biomedical polyurethane surfaces undergoing biodegradation.	2004-04	14978730
Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors.	2004-03	14718595
Metabolic analysis of acetate accumulation during xylose consumption by Paenibacillus polymyxa.	2004-03	14556038
Determination of gamma-hydroxybutyric acid in biological fluids by using capillary electrophoresis with indirect detection.	2004-02-05	14698260
Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen.	2004-01-26	14744611
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.	2004-01-16	14557277
Synthesis and characterization of polyurethane and poly(ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification.	2004-01-09	14698580
Development of a solid-phase extraction method for simultaneous extraction of adipic acid, succinic acid and 1,4-butanediol formed during hydrolysis of poly(butylene adipate) and poly(butylene succinate).	2004-01-02	14753784
Production of L-2,3-butanediol by a new pathway constructed in Escherichia coli.	2004	15548307
The gamma-hydroxybutyrate withdrawal syndrome.	2004	15298492
Gamma-hydroxybutyrate: bridging the clinical-analytical gap.	2004	15298491
Gamma-butyrolactone and 1,4-butanediol: abused analogues of gamma-hydroxybutyrate.	2004	15298490
Synthesis of double-headed 2-5A-antisense chimeras and their ability to activate human RNase L.	2003-11-17	14592484
Crosslinked poly(methyl vinyl ether-co-maleic anhydride) as topical vehicles for hydrophilic and lipophilic drugs.	2003-11-13	14612339
Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks.	2003-11-11	14606915
New Zealand's first fatality linked to use of 1,4-butanediol (1,4-B, Fantasy): no evidence of coingestion or comorbidity.	2003-10-24	14583808
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 30-2003. A 21-year-old man with sudden alteration of mental status.	2003-09-25	14507952
Aquatic toxicity of selected chemicals as a basic criterion for environmental classification.	2003-09	14677368
[Investigation of the cause of polyurethane catheter cracking during constant infusion of etoposide (VP-16) injection (2)--Analysis of ethanol eluting materials from catheter].	2003-09	14513771
Cellular interactions and degradation of aliphatic poly(ester amide)s derived from glycine and/or 4-amino butyric acid.	2003-09	12809774
Effects of temperature, inoculum size and starch hydrolyzate concentration on butanediol production by Bacillus licheniformis.	2003-09	12699930
Purification and characterization of novel salt-active acharan sulfate lyase from Bacteroides stercoris HJ-15.	2003-08	12869191
Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.	2003-07-25	12892832
Vertically stratified flows in microchannels. Computational simulations and applications to solvent extraction and ion exchange.	2003-07-15	14570209
Poly(ether ester amide)s for tissue engineering.	2003-07	12726718
[Synthesis, characterization and blood compatibility studies of biomedical aliphatic polyurethanes].	2003-06	12856596
Lipase-catalyzed polycondensations: effect of substrates and solvent on chain formation, dispersity, and end-group structure.	2003-05-14	12741768
Intoxication due to 1,4-butanediol.	2003-05-05	12787662
Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media.	2003-03	12882564
Synthesis of double-headed 2-5A-antisense chimeras and their ability to activate human RNase L.	2003	14510381
Surface characterization and platelet adhesion studies of aliphatic polyurethanes grafted by fluorocarbon oligomers: effect of fluorocarbon chain length and carboxylic acid group.	2002-01	15348203

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:33:37 GMT 2025` Edited by `admin` on `Mon Mar 31 17:33:37 GMT 2025`
Record UNII	3XUS85K0RA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTYLENE GLYCOL

Official Name

English

1,3-Butylene glycol

Preferred Name

English

1,3-BUTANEDIOL

Systematic Name

English

1,3-BUTYLENE GLYCOL [MI]

Common Name

English

NSC-402145

Code

English

1,3 BUTYLENE GLYCOL [FHFI]

Common Name

English

1,3-BUTYLENE GLYCOL [FCC]

Common Name

English

1,3-BUTANDIOL

Systematic Name

English

1,3-DIHYDROXYBUTANE

Systematic Name

English

1,3 BUTYLENE GLYCOL, (±)-

Common Name

English

BUTANE-1,3-DIOL

Systematic Name

English

1,3-BUTANEDIOL [HSDB]

Common Name

English

BUTYLENE GLYCOL [II]

Common Name

English

(RS)-1,3-BUTANDIOL

Systematic Name

English

1-METHYL-1,3-PROPANEDIOL

Systematic Name

English

BUTANE-1,3-DIOL [USP-RS]

Common Name

English

1,3-butandiol [WHO-DD]

Common Name

English

1,3 BUTYLENE GLYCOL

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

42205