U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1741 - 1750 of 2240 results

Status:
Possibly Marketed Outside US
First approved in 2010
Source:
Aquax Repellent by Pella Pharmaceuticals Co. Ltd
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

O-Cymen-5-OL is an antifungal preservative used in cosmetics and beauty products to prevent harmful bacteria from developing and to prolong the shelf-life of formulas. It is part of the Isopropyl Cresols family and is originally developed synthetically in the form of a crystal. O-Cymen-5-OL is also used as a cosmetic biocide, or ingredient that helps to cleanse the skin or to prevent odor by destroying or inhibiting the growth of microorganisms, according to research. O-Cymen-5-OL is approved by the FDA for use as a direct and indirect food additive and has been approved by the CIR for use in cosmetics up to .5% concentration. However, in the European Union, it is only approved for use up to .1%. Studies in Japan, some dating back to 1956, found O-Cymen-5-OL to be neurotoxic in animals and have led to heavier restrictions on its use in cosmetics there. O-Cymen-5-OL (Dekasol BL) is used in oral care, to fight periodontal disease.
Status:
Possibly Marketed Outside US
Source:
Canada:DECOQUINATE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Decoquinate is a quinolone derivative that is used in the control of coccidiosis in domestic animals. Decoquinate treats and prevents coccidiosis in chickens, cattle, goats, sheep, etc. Decoquinate acts on sporozoites development and prevents their penetration of the gut epithelium. Decoquinate inhibits mitochondrial respiration and electron transport in Eimeria.
Status:
Possibly Marketed Outside US
Source:
Canada:EMBUTRAMIDE
Source URL:
First approved in 2006

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Embutramide is a veterinary, CNS active medicine used for euthanasia in dogs. The drug is marketed under the name Tributame in the USA and under the name Tanax in Europe. Human consumption of the drug is usually associated with suicide attempts.
Clorsulon is a compound belonging to the benzenesulphonamide family. It is used in veterinary medicine for the treatment of liver fluke (monotherapy), gasrtointestinal and lung worms, lice, grubs and mites (in combination with ivermectin) in cattles. Clorsulon inhibits the enzymes involved in the glycolytic pathways of the common liver fluke (Fasciola hepatica or Fasciola gigantica), namely phosphoglycerate kinase and phosphoglyceromutase.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)



Luprostiol is a synthetic prostaglandin F2α and is a luteolytic agent. It is used for estrus control and termination of pregnancy in mares. In cattle Luprostiol is indicated for: - Oestrus regulation / oestrus synchronization; - Treatment of suboestrus; - Induction of abortion; - Induction of parturition; - Treatment of pyometra, chronic endometritis and fetal mummification.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Dibutyl phthalate (DBP) is used to help make plastics soft and flexible. It is used in shower curtains, raincoats, food wraps, bowls, car interiors, vinyl fabrics, floor tiles, and other products. Animal studies have reported developmental and reproductive effects from oral exposure. Dibutyl phthalate (DBP) is classified as a substance toxic to reproduction. No information is available on the carcinogenic effects of dibutyl phthalate in humans or animals. Treatment with dibutyl phthalate enhanced Aryl Hydrocarbon Receptor mRNA expression, which was reflected by the increased AhR protein level. ERα, ERβ, and PPARγ antagonists stimulated DBP-induced caspase-3 and LDH activities. AhR is involved in DBP-induced apoptosis and neurotoxicity, while the ERs and PPARγ signaling pathways are impaired by the phthalate. In vitro test showed that DBP killed all Demodex mites within 1 hour. Dibutyl phthalate emulsion is promising to be developed as a safe, effective therapeutic medicament on demodicidosis.

Showing 1741 - 1750 of 2240 results