U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 158781 - 158790 of 167129 results

Gallic acid is a polyphenol found in a variety of foods and herbs. Several studies have shown thta gallic acid has neuroprotective and anti-oxidant properties and can be a promising candidate for the treatment of cancer, cardiovascular diseases, neurodegenerative disorders, fatty liver disease and many others. Gallic acid acts by protecting cells against oxidative damage caused by reactive species often encountered in biological systems including, hydroxyl, superoxide and peroxyl and the non-radicals, hydrogen peroxide and hypochlorous acid. However, its ability to induce apoptosis, is mainly associated with its prooxidant, rather than antioxidant behavior.
Status:
US Previously Marketed
Source:
Strychnine U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Strychnine U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Strychnine is an indole alkaloid obtained from the seeds of the Indian tree Strychnos nux-vomica. It gets its scientific name “strychnos” from Carl Linnaeus, who classified it back in 1753, but it was known to the population of India way before then. Nux vomica originates in India. Strychnine-containing baits are currently labelled for below-ground use and are intended for the control of pocket gophers. Their use as indoor pesticides has been eliminated since 1989. In the past, strychnine has been used as a pesticide to control rats, moles, gophers, and coyotes. Strychnine is highly toxic to most domestic animals. Strychnine is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea.
Status:
US Previously Marketed
Source:
Cerium Oxalate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Cerium Oxalate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cerous iodide is a salt of lanthanide metal cerium (III) and iodide ion. In 1920s solution of cerous iodide for intravenous injection (called "introcid") was used as an antimicrobial agent for treating puerperal fever. It has shown prophylactic activity against sepsis, and was explored for its antineoplastic properties in patients with lymphogranulomatosis or inoperable solid tumors. According to the clinical reports, it has been applied with remarkable benefit, as indicated by tumor shrinkage and improved quality of life in several cases of locally advanced or metastatic tumors of different origin.
Status:
US Previously Marketed
Source:
Antimony Oxide N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Antimony Oxide N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.
Status:
US Previously Marketed
Source:
Diluted Hydrobromic Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Diluted Hydrobromic Acid U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Hydrobromic acid is a useful reagent for generating organobromine compounds. It was shown that hydrobromic acid could initiate or exacerbate inflammatory pulmonary disease.
Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair care, skin care, shaving, personal hygiene and suntan products.
Status:
US Previously Marketed
Source:
Chlorinated Lime U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Chlorinated Lime U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

CALCIUM CHLORIDE HYDROXIDE HYPOCHLORITE, DIHYDRATE is an inert ingredient in pesticide products.
Status:
US Previously Marketed
Source:
Antimony Oxide N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Antimony Oxide N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.
Status:
US Previously Marketed
Source:
Sodium Cyanide U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Cyanide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
sodium propionate
(1921)
Source URL:
First marketed in 1921
Source:
sodium propionate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Propionic acid (PA), also known as propanoic acid, with chemical formula C3H6O2, is an organic acid used as a food additive and found naturally on the skin and in the gastrointestinal tract. It is a byproduct of fermentation reactions and is also produced industrially from ethylene or ethanol and carbon monoxide. Propionic acid is a fungicide and bactericide, registered to controlfungi and bacteria in stored grains, hay, grain storage areas, poultry litter,and drinking water for livestock and poultry. As a food preservative, propionic acid prevents mold in bread and baked goods, and it is used as a flavoring agent in cheese and other packaged goods. The U.S. Environmental Protection Agency considers it safe and therefore, has no limitation on its use. It has been demonstrated that PA lowers fatty acids content in liver and plasma, reduces food intake, exerts immunosuppressive actions and probably improves tissue insulin sensitivity. Thus increased production of PA by the microbiota might be considered beneficial in the context of prevention of obesity and diabetes type 2. The molecular mechanisms by which PA may exert this plethora of physiological effects are slowly being elucidated and include intestinal cyclooxygenase enzyme, the G-protein coupled receptors 41 and 43 and activation of the peroxisome proliferator-activated receptor γ, in turn inhibiting the sentinel transcription factor NF-κB and thus increasing the threshold for inflammatory responses in general. Taken together, PA emerges as a major mediator in the link between nutrition, gut microbiota and physiology. The sodium salt of propionic acid was previously approved in Canada as an active ingredient in Amino-Cerv (used to treat inflammation or injury of the cervix).

Showing 158781 - 158790 of 167129 results