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Restrict the search for
alpha-tocopherol acetate
to a specific field?
Class (Stereo):
CHEMICAL (ABSOLUTE)
Disulergine is the synthetic 8 alpha-amino ergoline. Disulergine is the dopamine D2 receptor agonist and prolactin release inhibitor. Disulergine was as potent as dopamine in inhibiting growth hormone release but, in contrast to dopamine, was nearly ineffective in stimulating the secretion of the hormone.
Status:
Investigational
Source:
INN:levoprotiline [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Rifamexil (also known as MDL 62769 or P/DEA) is a derivative of rifamycin (a natural antibiotic produced by Amycolatopsis rifamycinica). This drug has greater intrinsic activity against Myobacterium avium (MAC) than rifampin. Information on current use of this compound is not available.
Status:
Investigational
Source:
NCT02365636: Phase 2 Interventional Completed Postherpetic Neuralgia
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Funapide (also known as TV 45070; XEN 402) is a small molecule blocker of the voltage-gated sodium channels Nav1.7 (SCN9A) and Nav1.8. Funapide was developed as a potential treatment of pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain. In April 2013, the US FDA granted orphan drug designation to funapide for the treatment of pain associated with erythromelalgia (EM). EM is a rare autosomal dominant condition characterized by debilitating spontaneous or easily evoked attacks of symmetrical burning pain in the feet and hands, typically associated with elevated skin temperature and erythema (redness of the skin). Funapide also was involved in phase II clinical trials in patients with post herpetic neuralgia and in participants with primary osteoarthritis (OA) affecting a single knee. On March 7, 2018, Teva Pharmaceutical and Xenon Pharmaceuticals entered into a mutual agreement to terminate the collaborative development and license agreement they entered into in 2012 for the pain drug funapide. The reason was that the top line results of funapide phase 2 study in post-herpetic neuralgia patients failed to meet the primary or secondary endpoints.
Class (Stereo):
CHEMICAL (ACHIRAL)
Picafibrate is clofibrate derivative. It is a hypocholesteraemic agent. Fibrates reduce plasma triglycerides by inhibiting their hepatic synthesis and increasing their catabolism. These effects are due to activation of peroxisome proliferator-activated receptors (PPAR alpha) and induction of the over-expression of genes containing a peroxisome proliferator response element (PPRE) in their promoter.
Class (Stereo):
CHEMICAL (RACEMIC)
Nisbuterol, a nicotinic acid ester, is a bronchodilator.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Salmisteine was studied as an antipyretic and mucolytic agent. Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Etisulergine (CQ 32-084) is an ergoline derivative. Etisulergine stimulates both dopamine D1- and D2-receptors, antagonizes alpha-adrenergic and serotonin 5-HT2 receptors. Etisulergine demonstrated antiparkinsonian activity in patients.
Class (Stereo):
CHEMICAL (ACHIRAL)
Etofenprox is a synthetic pyrethroid insecticide compound used in agricultural production. Etofenprox acts on the nervous system of insects by disrupting their neuron sodium channels. Etofenprox is a contact-kill adulticide used to control a wide variety of insects including weevils, beetles, aphids, moths, whiteflies, thrips, borers, fleas and mosquitoes. Etofenprox is well tolerated by mammals, including cats, and is environmentally friendly.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Nolomirole (CHF1035) is an orally active, selective dopamine agonist, primarily activating DA2- and alpha2 receptors, thereby inhibiting norepinephrine release, which may be beneficial in heart failure. Nolomirole is able to attenuate the heart failure signs in the monocrotaline-induced congestive heart failure. CHF1035 is a mixture of two enantiomers, CHF1800 (+) and CHF1810 (-). CHF1035 and its metabolite CHF1024 significantly decreased the IOP in rabbits, and are potential novel IOP lowering agents. Especially, CHF1035 produced a substantial decrease in IOP for a prolonged period of time, and thus may prove useful in glaucoma therapy. Nolomirole is a pre-synaptic stimulator of DA2-dopaminergic and α2-adrenergic receptors in peripheral sympathetic nerve endings. These receptors act as a negative feedback mechanism, inhibiting norepinephrine secretion. In early phase clinical studies lasting 1–3 months, nolomirole reduced peripheral systemic resistance and 24 hour blood pressure and increased cardiac output. In a study of 29 patients with heart failure, followed for 10 days, a reduction in plasma norepinephrine was demonstrated. In spite of the fact that Nolomirole was in clinical trials for the treatment of heart failure, its development was discontinued.
