DISULERGINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H24N4O2S
Molecular Weight	348.463
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)S(=O)(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=C3C2=CC=C4)N(C)C1

InChI

InChIKey=VUEGYUOUAAVYAS-JGGQBBKZSA-N

InChI=1S/C17H24N4O2S/c1-20(2)24(22,23)19-12-8-14-13-5-4-6-15-17(13)11(9-18-15)7-16(14)21(3)10-12/h4-6,9,12,14,16,18-19H,7-8,10H2,1-3H3/t12-,14+,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H24N4O2S
Molecular Weight	348.463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/520501 | https://www.ncbi.nlm.nih.gov/pubmed/7107817 | https://www.ncbi.nlm.nih.gov/pubmed/2569406

Disulergine is the synthetic 8 alpha-amino ergoline. Disulergine is the dopamine D2 receptor agonist and prolactin release inhibitor. Disulergine was as potent as dopamine in inhibiting growth hormone release but, in contrast to dopamine, was nearly ineffective in stimulating the secretion of the hormone.

Approval Year

PubMed

Title	Date	PubMed
Amphetamine discrimination: effects of dopamine receptor agonists.	1989-01-31	2569406
Dopaminergic activity of some ergot alkaloid derivatives: relationship to their chemical structure.	1986	2938196
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.	1985-06	2863299
Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines.	1984-06-01	6468500
In vitro effect of dopamine on growth hormone (GH) release from human GH-secreting pituitary adenomas.	1982-10	7107817
Effect of bromocriptine, ergotamine and other ergot alkaloids on the hormone secretion and growth of a rat pituitary tumour.	1980-07	7430884
Two novel prolactin release-inhibiting 8 alpha-amino-ergolines.	1979-12-15	520501

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:55 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:55 GMT 2025`
Record UNII	1Q3CYC1YR6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISULERGINE

Official Name

English

SULERGINE

Preferred Name

English

disulergine [INN]

Common Name

English

N,N-DIMETHYL-N'-(6-METHYLERGOLIN-8.ALPHA.-YL)SULFAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47794