DISULERGINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H24N4O2S
Molecular Weight	348.463
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(C)C

InChI

InChIKey=VUEGYUOUAAVYAS-JGGQBBKZSA-N

InChI=1S/C17H24N4O2S/c1-20(2)24(22,23)19-12-8-14-13-5-4-6-15-17(13)11(9-18-15)7-16(14)21(3)10-12/h4-6,9,12,14,16,18-19H,7-8,10H2,1-3H3/t12-,14+,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H24N4O2S
Molecular Weight	348.463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/520501 | https://www.ncbi.nlm.nih.gov/pubmed/7107817 | https://www.ncbi.nlm.nih.gov/pubmed/2569406

Disulergine is the synthetic 8 alpha-amino ergoline. Disulergine is the dopamine D2 receptor agonist and prolactin release inhibitor. Disulergine was as potent as dopamine in inhibiting growth hormone release but, in contrast to dopamine, was nearly ineffective in stimulating the secretion of the hormone.

Approval Year

PubMed

Title	Date	PubMed
Effect of bromocriptine, ergotamine and other ergot alkaloids on the hormone secretion and growth of a rat pituitary tumour.	1980 Jul	7430884
Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines.	1984 Jun 1	6468500
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.	1985 Jun	2863299
Amphetamine discrimination: effects of dopamine receptor agonists.	1989 Jan 31	2569406

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:21:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:21:21 GMT 2023`
Record UNII	1Q3CYC1YR6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISULERGINE

Official Name

English

disulergine [INN]

Common Name

English

N,N-DIMETHYL-N'-(6-METHYLERGOLIN-8.ALPHA.-YL)SULFAMIDE

Systematic Name

English

SULERGINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47794