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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
NCT01803074: Phase 2 Interventional Completed Infection, Human Immunodeficiency Virus
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT01232595: Phase 2 Interventional Completed Moderate Clostridium Difficile Infection
(2010)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
LFF-571 is a novel semisynthetic thiopeptide antibiotic with potent activity against a variety of Gram-positive pathogens, including Clostridium difficile. LFF-571 was generally safe and well tolerated in single and multiple oral doses in healthy subjects. There were no deaths, no serious adverse events, and no subject withdrawals due to an adverse event. The most common adverse event was diarrhea, gastrointestinal pain or distension was also noted. Similar to healthy volunteers, patients with C. difficile infections exhibited high fecal concentrations and low serum levels of LFF571. Novartis is developing oral LFF 571 for the treatment of Clostridium difficile infections. LFF 571 binds to bacterial elongation factor Tu (EF-Tu) in domain 2. Phase-II development is ongoing in USA and Canada.
Status:
Investigational
Source:
NCT02253940: Phase 1 Interventional Completed Healthy
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT02687152: Phase 1/Phase 2 Interventional Completed Type 2 Diabetes Mellitus
(2014)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
N(ω)-hydroxy-nor-L-arginine (nor-NOHA), an arginase inhibitor, has therapeutic potential in the treatment of cardiovascular and obstructive airway diseases. Nor-NOHA is a reversible, competitive arginase inhibitor. The affinity of nor-NOHA for the to the arginase active site was found in the nanomolar range. Nor-NOHA has proven to be one of the strongest arginase inhibitors. Inhibition by nor-NOHA is ten times more potent on arginase II than on arginase I. The pharmacokinetics of nor-NOHA is characterized by high bioavailability, close to 100% after multiple dose and rapid elimination resulting in t1/2 of 15–30 min after intravenous and intraperitoneal administration to rats. Arginase inhibition with Nor-NOHA increased circulating arginine levels and decreased hepatic damage during liver I/R injury. Arginase blockade represents a potentially novel strategy to combat hepatic I/R injury associated with liver transplantation. Nor-NOHA is under investigation in clinical trial NCT02009527 (Arginase inhibition in ischemia-reperfusion injury).
Status:
Investigational
Source:
NCT03600649: Phase 1 Interventional Active, not recruiting Ewing Sarcoma
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03947385: Phase 1/Phase 2 Interventional Recruiting Metastatic Uveal Melanoma
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT02765165: Phase 1/Phase 2 Interventional Terminated Solid Tumors (Phase 1)
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT00838162: Phase 2 Interventional Completed Human Immunodeficiency Virus Type 1
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
ASC-09 orTMC-310911, a HIV protease inhibitor, participated in phase II clinical for the treatment of Human Immunodeficiency Virus Type 1. However, no recent development has been reported.
Status:
Investigational
Source:
NCT01297088: Phase 1 Interventional Completed Diagnostic Imaging
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
BAY-86-9596 (D-18F-FMT, or O-18F-fluoromethyl-D-tyrosine) was developed as an agent not only for tumor detection but also for monitoring early-phase response to radiation therapy by positron emission tomography (PET). This drug participated in clinical trials for patients with inflammation and solid tumors, but further information about trials is not available.
Status:
Investigational
Source:
NCT01184508: Phase 2 Interventional Terminated Migraine Headache
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
LY2300559 is a dual metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator and cysteinyl leukotriene receptor 1 (CysLTR1) antagonist. Eli Lilly was developing LY2300559 for the prevention of migraine. LY2300559 development has been discontinued.
