USL-311

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H34N6O
Molecular Weight	422.5664
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1CCC(CC1)N2CCCN(CC2)C3=CC=CC(=N3)C(=O)NC4=CC=NC=C4

InChI

InChIKey=XNUNVQKARNSSEO-UHFFFAOYSA-N

InChI=1S/C24H34N6O/c1-19(2)28-15-9-21(10-16-28)29-13-4-14-30(18-17-29)23-6-3-5-22(27-23)24(31)26-20-7-11-25-12-8-20/h3,5-8,11-12,19,21H,4,9-10,13-18H2,1-2H3,(H,25,26,31)

HIDE SMILES / InChI

Molecular Formula	C24H34N6O
Molecular Weight	422.5664
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Analyte	Population
48.2 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	60 mg/m² single, intravenous dose: 60 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
69.1 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	120 mg/m² single, intravenous dose: 120 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
200 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	180 mg/m² single, intravenous dose: 180 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
168 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	180 mg/m² single, intravenous dose: 180 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
107 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	250 mg/m² single, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.06 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.74 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6.68 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	160 mg single, oral dose: 160 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
181 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	60 mg/m² single, intravenous dose: 60 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
437 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	120 mg/m² single, intravenous dose: 120 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
711 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	180 mg/m² single, intravenous dose: 180 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
1193 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	180 mg/m² single, intravenous dose: 180 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1059 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	250 mg/m² single, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5.95 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
16.4 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
30.4 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT02765165	160 mg single, oral dose: 160 mg route of administration: Oral experiment type: SINGLE co-administered:	USL-311 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
80% CLINICAL TRIAL https://classic.clinicaltrials.gov/ProvidedDocs/65/NCT02765165/Prot_000.pdf			USL-311 plasma	Homo sapiens

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:09:45 GMT 2025` Edited by `admin` on `Mon Mar 31 23:09:45 GMT 2025`
Record UNII	2BTG5MX2Q2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

USL311

Preferred Name

English

USL-311

Common Name

English

2-PYRIDINECARBOXAMIDE, 6-(HEXAHYDRO-4-(1-(1-METHYLETHYL)-4-PIPERIDINYL)-1H-1,4-DIAZEPIN-1-YL)-N-4-PYRIDINYL-

Systematic Name

English

USL 311 [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

503415